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Lymphoma developed in all three lineages, and the incidence of lymphoma increased significantly with age with lymphomas developing in 42% of transgenic mice over 18 months. The expression of LMP1 was detected at high levels in the lymphoma tissues but only at trace levels in normal lymphoid tissues. Gene rearrangement of the Ig heavy chain indicated monoclonality or oligoclonality in all lymphomas, some of the lymphoid hyperplastic spleens, and some histologically normal spleens. These data reveal that LMP1, without the expression of other EBV genes, is oncogenic\n                    <jats:italic>in vivo<\/jats:italic>\n                    and indicate that LMP1 is a major contributing factor to the development of EBV-associated lymphomas.\n                  <\/jats:p>","DOI":"10.1073\/pnas.95.20.11963","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:40:11Z","timestamp":1027680011000},"page":"11963-11968","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":333,"title":["Expression of the Epstein\u2013Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice"],"prefix":"10.1073","volume":"95","author":[{"given":"Wanla","family":"Kulwichit","sequence":"first","affiliation":[{"name":"Lineberger Comprehensive Cancer Center, Departments of Medicine, Microbiology and Immunology, and Pathology, University of North Carolina at Chapel Hill, Chapel Hill, NC 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