{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:02:28Z","timestamp":1781103748807,"version":"3.54.1"},"reference-count":18,"publisher":"National Academy of Sciences","issue":"21","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1998,10,13]]},"abstract":"<jats:p>\n                    The\n                    <jats:italic>mahogany<\/jats:italic>\n                    (\n                    <jats:italic>mg<\/jats:italic>\n                    ) locus originally was identified as a recessive suppressor of\n                    <jats:italic>agouti<\/jats:italic>\n                    , a locus encoding a skin peptide that modifies coat color by antagonizing the melanocyte-stimulating hormone receptor or MC1-R. Certain dominant alleles of\n                    <jats:italic>agouti<\/jats:italic>\n                    cause an obesity syndrome when ectopic expression of the peptide aberrantly antagonizes the MC4-R, a related melanocyte-stimulating hormone receptor expressed in hypothalamic circuitry and involved in the regulation of feeding behavior and metabolism. Recent work has demonstrated that\n                    <jats:italic>mg<\/jats:italic>\n                    , when homozygous, blocks not only the ability of\n                    <jats:italic>agouti<\/jats:italic>\n                    to induce a yellow coat color when expressed in the skin of the\n                    <jats:italic>lethal yellow<\/jats:italic>\n                    mouse (\n                    <jats:italic>\n                      A\n                      <jats:sup>Y<\/jats:sup>\n                    <\/jats:italic>\n                    ), but also the obesity resulting from ectopic expression of\n                    <jats:italic>agouti<\/jats:italic>\n                    in the brain. Detailed analysis of\n                    <jats:italic>\n                      mg\/mg A\n                      <jats:sup>Y<\/jats:sup>\n                      \/a\n                    <\/jats:italic>\n                    animals, presented here, demonstrates that\n                    <jats:italic>mg\/mg<\/jats:italic>\n                    blocks the obesity, hyperinsulinemia, and increased linear growth induced by ectopic expression of the agouti peptide. Remarkably, however,\n                    <jats:italic>mg\/mg<\/jats:italic>\n                    did not reduce hyperphagia in the\n                    <jats:italic>\n                      A\n                      <jats:sup>Y<\/jats:sup>\n                      \/a\n                    <\/jats:italic>\n                    mouse. Furthermore,\n                    <jats:italic>mg\/mg<\/jats:italic>\n                    induced hyperphagia and an increase in basal metabolic rate in the C57BL\/6J mouse in the absence of\n                    <jats:italic>\n                      A\n                      <jats:sup>Y<\/jats:sup>\n                    <\/jats:italic>\n                    . Consequently, although\n                    <jats:italic>mahogany<\/jats:italic>\n                    is broadly required for agouti peptide action, it also appears to be involved in the control of metabolic rate and feeding behavior independent of its suppression of\n                    <jats:italic>agouti<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1073\/pnas.95.21.12707","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:40:11Z","timestamp":1027680011000},"page":"12707-12712","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":71,"title":["<i>Mahogany<\/i>\n                    (\n                    <i>mg<\/i>\n                    ) stimulates feeding and increases basal metabolic rate independent of its suppression of\n                    <i>agouti<\/i>"],"prefix":"10.1073","volume":"95","author":[{"given":"Daniela M.","family":"Dinulescu","sequence":"first","affiliation":[{"name":"Vollum Institute, Departments of Cell and Developmental Biology, and Pediatrics, Oregon Health Sciences University, Portland, OR 97201; Department of Veterinary Pathobiology, Texas A &amp; M University, College Station, TX 77843; and Millennium Pharmaceuticals, Inc., 640 Memorial Drive, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fan","sequence":"additional","affiliation":[{"name":"Vollum Institute, Departments of Cell and Developmental Biology, and Pediatrics, Oregon Health Sciences University, Portland, OR 97201; Department of Veterinary Pathobiology, Texas A &amp; M University, College Station, TX 77843; and Millennium Pharmaceuticals, Inc., 640 Memorial Drive, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Boston","sequence":"additional","affiliation":[{"name":"Vollum Institute, Departments of Cell and Developmental Biology, and Pediatrics, Oregon Health Sciences University, Portland, OR 97201; Department of Veterinary Pathobiology, Texas A &amp; M University, College Station, TX 77843; and Millennium Pharmaceuticals, Inc., 640 Memorial Drive, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"McCall","sequence":"additional","affiliation":[{"name":"Vollum Institute, Departments of Cell and Developmental Biology, and Pediatrics, Oregon Health Sciences University, Portland, OR 97201; Department of Veterinary Pathobiology, Texas A &amp; M University, College Station, TX 77843; and Millennium Pharmaceuticals, Inc., 640 Memorial Drive, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Lynn","family":"Lamoreux","sequence":"additional","affiliation":[{"name":"Vollum Institute, Departments of Cell and Developmental Biology, and Pediatrics, Oregon Health Sciences University, Portland, OR 97201; Department of Veterinary Pathobiology, Texas A &amp; M University, College Station, TX 77843; and Millennium Pharmaceuticals, Inc., 640 Memorial Drive, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen J.","family":"Moore","sequence":"additional","affiliation":[{"name":"Vollum Institute, Departments of Cell and Developmental Biology, and Pediatrics, Oregon Health Sciences University, Portland, OR 97201; Department of Veterinary Pathobiology, Texas A &amp; M University, College Station, TX 77843; and Millennium Pharmaceuticals, Inc., 640 Memorial Drive, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Montagno","sequence":"additional","affiliation":[{"name":"Vollum Institute, Departments of Cell and Developmental Biology, and Pediatrics, Oregon Health Sciences University, Portland, OR 97201; Department of Veterinary Pathobiology, Texas A &amp; M University, College Station, TX 77843; and Millennium Pharmaceuticals, Inc., 640 Memorial Drive, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger D.","family":"Cone","sequence":"additional","affiliation":[{"name":"Vollum Institute, Departments of Cell and Developmental Biology, and Pediatrics, Oregon Health Sciences University, Portland, OR 97201; Department of Veterinary Pathobiology, Texas A &amp; M University, College Station, TX 77843; and Millennium Pharmaceuticals, Inc., 640 Memorial Drive, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1998,10,13]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/371799a0"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/mend.11.3.9898"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(05)80067-4"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.7.2562"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)82452-8"},{"key":"e_1_3_3_6_2","first-page":"1298","volume":"8","author":"Mountjoy K G","year":"1994","unstructured":"K G Mountjoy, M T Mortrud, M J Low, R B Simerly, R D Cone Mol Endocrinol 8, 1298\u20131308 (1994).","journal-title":"Mol Endocrinol"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/385165a0"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81865-6"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5335.135"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.5.593"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1197-273"},{"key":"e_1_3_3_12_2","first-page":"35","volume":"22","author":"Lane P W","year":"1960","unstructured":"P W Lane Mouse News Lett 22, 35 (1960).","journal-title":"Mouse News Lett"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a106996"},{"key":"e_1_3_3_14_2","first-page":"12","volume-title":"Genetic Variants and Strains of the Laboratory Mouse","author":"Green M C","year":"1989","unstructured":"M C Green Genetic Variants and Strains of the Laboratory Mouse, eds M F Lyon, A G Searle (Oxford Univ. 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