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Similar to VEGF, the angiogenic response of corneas induced by VEGF-C is intensive, with a high density of new capillaries. However, the outgrowth of microvessels stimulated by VEGF-C was significantly longer than that induced by VEGF. In the developing embryo, VEGF-C was able to induce branch sprouts from the established blood vessels. VEGF-C also induced an elongated, spindle-like cell shape change and actin reorganization in both VEGF receptor (VEGFR)-2 and VEGFR-3-overexpressing endothelial cells, but not in VEGFR-1-expressing cells. Further, both VEGFR-2 and VEGFR-3 could mediate proliferative and chemotactic responses in endothelial cells on VEGF-C stimulation. Thus, VEGF-C may regulate physiological angiogenesis and participate in the development and progression of angiogenic diseases in addition to lymphangiogenesis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.95.24.14389","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:40:11Z","timestamp":1027680011000},"page":"14389-14394","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":462,"title":["Vascular endothelial growth factor C induces angiogenesis\n                    <i>in vivo<\/i>"],"prefix":"10.1073","volume":"95","author":[{"given":"Yihai","family":"Cao","sequence":"first","affiliation":[{"name":"Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, S-171 77 Stockholm, Sweden; Department of Surgery, Brigham and Women\u2019s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115; Molecular\/Cancer Biology Laboratory, Haartman Institute, PL 21, University of Helsinki, 00014 Helsinki, Finland; and Department of Medical and Physiological Chemistry, Biomedical Center, Box 575, S-751 23 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Linden","sequence":"additional","affiliation":[{"name":"Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, S-171 77 Stockholm, Sweden; Department of Surgery, Brigham and Women\u2019s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115; Molecular\/Cancer Biology Laboratory, Haartman Institute, PL 21, University of Helsinki, 00014 Helsinki, Finland; and Department of Medical and Physiological Chemistry, Biomedical Center, Box 575, S-751 23 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Farnebo","sequence":"additional","affiliation":[{"name":"Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, 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Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, S-171 77 Stockholm, Sweden; Department of Surgery, Brigham and Women\u2019s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115; Molecular\/Cancer Biology Laboratory, Haartman Institute, PL 21, University of Helsinki, 00014 Helsinki, Finland; and Department of Medical and Physiological Chemistry, Biomedical Center, Box 575, S-751 23 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, S-171 77 Stockholm, Sweden; Department of Surgery, Brigham and Women\u2019s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115; Molecular\/Cancer Biology Laboratory, Haartman Institute, PL 21, University of Helsinki, 00014 Helsinki, Finland; and Department of Medical and Physiological Chemistry, Biomedical Center, Box 575, S-751 23 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Hua","family":"Qi","sequence":"additional","affiliation":[{"name":"Laboratory of Angiogenesis Research, Microbiology and Tumor Biology Center, Karolinska Institutet, S-171 77 Stockholm, Sweden; Department of Surgery, Brigham and Women\u2019s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115; Molecular\/Cancer Biology Laboratory, Haartman Institute, PL 21, University of Helsinki, 00014 Helsinki, Finland; and Department of Medical and Physiological Chemistry, Biomedical Center, Box 575, S-751 23 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Claesson-Welsh","sequence":"additional","affiliation":[{"name":"Laboratory of Angiogenesis 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