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Exposure of neutrophils to aspirin or sodium salicylate (poor COX inhibitor) inhibited Erk activity and adhesiveness of\n                    <jats:italic>formyl<\/jats:italic>\n                    methionyl-leucyl-phenylalanine- and arachidonic acid-stimulated neutrophils, consistent with anti-inflammation but not COX inhibition (IC\n                    <jats:sub>50<\/jats:sub>\n                    s = 1\u20138 mM). In contrast, indomethacin blocked neither Erk nor adhesion. Inhibition of Mek (proximal activator of Erk) also blocked stimulation of Erk and adhesion by\n                    <jats:italic>formyl<\/jats:italic>\n                    methionyl-leucyl-phenylalanineand arachidonic acid. Salicylate inhibition of Erk was independent of protein kinase A activation and generation of extracellular adenosine. These data are consistent with a role for Erk in stimulated neutrophil adhesion, and suggest that anti-inflammatory effects of salicylates may be mediated via inhibition of Erk signaling required for integrin-mediated responses.\n                  <\/jats:p>","DOI":"10.1073\/pnas.95.24.14540","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:40:11Z","timestamp":1027680011000},"page":"14540-14545","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":145,"title":["Modes of action of aspirin-like drugs: Salicylates inhibit Erk activation and integrin-dependent neutrophil adhesion"],"prefix":"10.1073","volume":"95","author":[{"given":"Michael H.","family":"Pillinger","sequence":"first","affiliation":[{"name":"Department of Medicine, Room NB16N1, New York University Medical Center, 550 First Avenue, New York, NY 10016; and Department of Rheumatology, Hospital for Joint Diseases, 301 East 17th Street, 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