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When introduced locally to balloon-injured rat carotid arteries, a well characterized model of a VSMC-derived lesion, Ad-FasL functioned as a potent inhibitor of neointima formation. In rats immunized with an empty adenoviral vector, robust T cell infiltration of the vessel wall was detected after local delivery of a \u03b2-galactosidase-expressing virus (Ad-\u03b2gal), whereas T cell infiltrates were not detected after local delivery of Ad-FasL. Prior immunization prevented \u03b2-galactosidase expression from Ad-\u03b2gal, whereas the expression of the FasL transgene was unaffected. When Ad-\u03b2gal and Ad-FasL were delivered together to preimmunized animals, T cell infiltration was reduced and \u03b2-galactosidase expression was restored. These data demonstrate that Fas ligand gene transfer can effectively inhibit injury-induced vessel lesion formation and can allow adenovirus-harboring cells to evade immune destruction.<\/jats:p>","DOI":"10.1073\/pnas.95.3.1213","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:42:40Z","timestamp":1027680160000},"page":"1213-1217","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":117,"title":["Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell\u2009response"],"prefix":"10.1073","volume":"95","author":[{"given":"Masataka","family":"Sata","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Research, St. Elizabeth\u2019s Medical Center, Tufts University School of Medicine, Boston, MA 02135; Department of Physiology, University of Massachusetts Medical Center, Worcester, MA 01655; Program in Cell, Molecular, and 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