{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:00:52Z","timestamp":1791414052714,"version":"4.3.3"},"reference-count":38,"publisher":"National Academy of Sciences","issue":"8","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1998,4,14]]},"abstract":"<jats:p>\n                    The\n                    <jats:italic>TEL<\/jats:italic>\n                    (\n                    <jats:italic>ETV6<\/jats:italic>\n                    )\u2212\n                    <jats:italic>AML1<\/jats:italic>\n                    (\n                    <jats:italic>CBFA2<\/jats:italic>\n                    ) gene fusion is the most common reciprocal chromosomal rearrangement in childhood cancer occurring in \u224825% of the most predominant subtype of leukemia\u2014 common acute lymphoblastic leukemia. The\n                    <jats:italic>TEL-AML1<\/jats:italic>\n                    genomic sequence has been characterized in a pair of monozygotic twins diagnosed at ages 3 years, 6 months and 4 years, 10 months with common acute lymphoblastic leukemia. The twin leukemic DNA shared the same unique (or clonotypic) but nonconstitutive\n                    <jats:italic>TEL-AML1<\/jats:italic>\n                    fusion sequence. The most plausible explanation for this finding is a single cell origin of the\n                    <jats:italic>TEL-AML<\/jats:italic>\n                    fusion in one fetus\n                    <jats:italic>in utero<\/jats:italic>\n                    , probably as a leukemia-initiating mutation, followed by intraplacental metastasis of clonal progeny to the other twin. Clonal identity is further supported by the finding that the leukemic cells in the two twins shared an identical rearranged\n                    <jats:italic>IGH<\/jats:italic>\n                    allele. These data have implications for the etiology and natural history of childhood leukemia.\n                  <\/jats:p>","DOI":"10.1073\/pnas.95.8.4584","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:42:40Z","timestamp":1027680160000},"page":"4584-4588","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":281,"title":["Fetal origins of the\n                    <i>TEL-AML1<\/i>\n                    fusion gene in identical twins with leukemia"],"prefix":"10.1073","volume":"95","author":[{"given":"Anthony M.","family":"Ford","sequence":"first","affiliation":[{"name":"Leukaemia Research Fund Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, United Kingdom; and Dutch Childhood Leukemia Study Group (DCLSG), Leyweg 299, P.O. Box 43515, 2504 AM The Hague, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline A.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Leukaemia Research Fund Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, United Kingdom; and Dutch Childhood Leukemia Study Group (DCLSG), Leyweg 299, P.O. Box 43515, 2504 AM The Hague, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy M.","family":"Price","sequence":"additional","affiliation":[{"name":"Leukaemia Research Fund Centre, Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, United Kingdom; and Dutch Childhood Leukemia Study Group (DCLSG), Leyweg 299, P.O. Box 43515, 2504 AM The Hague, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C. 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