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In this report, we localize an \u2248200-kDa integral membrane protein, CpABC, from\n                    <jats:italic>Cryptosporidium parvum<\/jats:italic>\n                    to the host\u2013parasite boundary, possibly the feeder organelle. The predicted amino acid sequence of CpABC has significant structural similarity with the cystic fibrosis conductance regulator and the multidrug resistance protein subfamily of ATP-binding cassette proteins. 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