{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:30:13Z","timestamp":1793316613796,"version":"4.5.0"},"reference-count":44,"publisher":"National Academy of Sciences","issue":"11","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1999,5,25]]},"abstract":"<jats:p>\n                    The\n                    <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    NPR1 has been shown to be a key regulator of gene expression during the onset of a plant disease-resistance response known as systemic acquired resistance. The\n                    <jats:italic>npr1<\/jats:italic>\n                    mutant plants fail to respond to systemic acquired resistance-inducing signals such as salicylic acid (SA), or express SA-induced pathogenesis-related (\n                    <jats:italic>PR<\/jats:italic>\n                    ) genes. Using NPR1 as bait in a yeast two-hybrid screen, we identified a subclass of transcription factors in the basic leucine zipper protein family (AHBP-1b and TGA6) and showed that they interact specifically in yeast and\n                    <jats:italic>in vitro<\/jats:italic>\n                    with NPR1. Point mutations that abolish the NPR1 function in\n                    <jats:italic>A. thaliana<\/jats:italic>\n                    also impair the interactions between NPR1 and the transcription factors in the yeast two-hybrid assay. Furthermore, a gel mobility shift assay showed that the purified transcription factor protein, AHBP-1b, binds specifically to an SA-responsive promoter element of the\n                    <jats:italic>A. thaliana PR-1<\/jats:italic>\n                    gene. These data suggest that NPR1 may regulate\n                    <jats:italic>PR-1<\/jats:italic>\n                    gene expression by interacting with a subclass of basic leucine zipper protein transcription factors.\n                  <\/jats:p>","DOI":"10.1073\/pnas.96.11.6523","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:39:15Z","timestamp":1027679955000},"page":"6523-6528","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":587,"title":["Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the\n                    <i>PR-1<\/i>\n                    gene"],"prefix":"10.1073","volume":"96","author":[{"given":"Yuelin","family":"Zhang","sequence":"first","affiliation":[{"name":"Developmental, Cell, and Molecular Biology Group, Department of Botany, Box 91000, Duke University, Durham, NC 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