{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:27:03Z","timestamp":1791898023535,"version":"4.3.4"},"reference-count":8,"publisher":"National Academy of Sciences","issue":"14","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1999,7,6]]},"abstract":"<jats:p>Painful peripheral neuropathies are precipitated by nerve injury\n from disease or trauma. All such injuries will be accompanied by an\n inflammatory reaction, a neuritis, that will mobilize the immune\n system. The role of the inflammation itself is difficult to determine\n in the presence of structural damage to the nerve. A method has been\n devised to produce a focal neuritis in the rat sciatic nerve that\n involves no more than trivial structural damage to the nerve. This\n experimental focal neuritis produces neuropathic pain sensations (heat-\n and mechano-hyperalgesia, and cold- and mechano-allodynia) in the\n ipsilateral hind paw. The abnormal pain sensations begin in 1\u20132 days\n and last for 4\u20136 days, with a subsequent return to normal. These\n results suggest that there is a neuroimmune interaction that occurs at\n the outset of nerve injury (and perhaps episodically over time in slow\n developing conditions like diabetic neuropathy) that produces\n neuropathic pain. The short duration of the phenomena suggest that they\n may prime the system for more slowly developing mechanisms of abnormal\n pain (e.g., ectopic discharge in axotomized primary afferent neurons)\n that underlie the chronic phase of painful neuropathy.<\/jats:p>","DOI":"10.1073\/pnas.96.14.7737","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:38:21Z","timestamp":1027679901000},"page":"7737-7738","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":56,"title":["Does a neuroimmune interaction contribute to the genesis of painful peripheral neuropathies?"],"prefix":"10.1073","volume":"96","author":[{"given":"Gary J.","family":"Bennett","sequence":"first","affiliation":[{"name":"Department of Neurology, MCP Hahnemann University, Philadelphia, PA\r 19102"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1999,7,6]]},"reference":[{"key":"e_1_3_2_1_2","unstructured":"Eliav E. Herzberg U. Ruda M. A. & Bennett G. J. (1999) Pain in press."},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90026-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90209-6"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)90013-2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)90023-X"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199503150-00006"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199611250-00018"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(97)00154-1"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.96.14.7737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T15:40:25Z","timestamp":1649864425000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.96.14.7737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7,6]]},"references-count":8,"journal-issue":{"issue":"14","published-print":{"date-parts":[[1999,7,6]]}},"alternative-id":["10.1073\/pnas.96.14.7737"],"URL":"https:\/\/doi.org\/10.1073\/pnas.96.14.7737","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7,6]]},"assertion":[{"value":"1999-07-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}