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Although the role of p21 in cell cycle regulation is well documented, there is little information concerning its role in antibody-mediated apoptosis. In the present study, we examined the involvement of p21 in the regulation of apoptosis by suppressing its induction in anti-IgM-treated Daudi cells through a p21 antisense expression construct approach. Reduction in induced p21 protein levels resulted in diminished G\n                    <jats:sub>1<\/jats:sub>\n                    arrest and increased apoptosis. The increased susceptibility to anti-IgM-mediated apoptosis was associated with increased caspase-3-like activity and poly-(ADP)ribose polymerase cleavage. These data suggest that p21 may directly interfere with the caspase cascade, thus playing a dual role in regulating both cell cycle progression and apoptosis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.96.15.8711","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:38:21Z","timestamp":1027679901000},"page":"8711-8715","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":34,"title":["Cancer dormancy and cell signaling: Induction of p21\n                    <sup>waf1<\/sup>\n                    initiated by membrane IgM engagement increases survival of B lymphoma cells"],"prefix":"10.1073","volume":"96","author":[{"given":"Radu","family":"Marches","sequence":"first","affiliation":[{"name":"Cancer Immunobiology Center and Department of Microbiology, and Laboratory of Molecular Pathology and Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Hsueh","sequence":"additional","affiliation":[{"name":"Cancer Immunobiology Center and Department of Microbiology, and Laboratory of Molecular Pathology and Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Uhr","sequence":"additional","affiliation":[{"name":"Cancer Immunobiology Center and Department of Microbiology, and Laboratory of Molecular Pathology and Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1999,7,20]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.10.6.3003-3012.1990"},{"key":"e_1_3_3_2_2","first-page":"5045S","volume":"51","author":"Uhr J W","year":"1991","unstructured":"J W Uhr, T Tucker, R D May, H Siu, E S Vitetta Cancer Res 51, 5045S\u20135053S (1991).","journal-title":"Cancer Res"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.5.1829"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.4.1539"},{"key":"e_1_3_3_5_2","first-page":"125","volume":"2","author":"Marches R","year":"1996","unstructured":"R Marches, E Racila, T F Tucker, L Picker, P Mongini, R Hsueh, E S Vitetta, R H Scheuermann, J W Uhr Ther Immunol 2, 125\u2013136 (1996).","journal-title":"Ther Immunol"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830200810"},{"key":"e_1_3_3_7_2","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.4049\/jimmunol.147.7.2411","volume":"147","author":"Beckwith M","year":"1991","unstructured":"M Beckwith, W J Urba, D K Ferris, C E Freter, D B Kuhns, C M Moratz, D L Longo J Immunol 147, 2411\u20132418 (1991).","journal-title":"J Immunol"},{"key":"e_1_3_3_8_2","first-page":"51","volume":"6","author":"Joseph L F","year":"1995","unstructured":"L F Joseph, S Ezhevsky, D W Scott Cell Growth Differ 6, 51\u201357 (1995).","journal-title":"Cell Growth Differ"},{"key":"e_1_3_3_9_2","first-page":"61","volume":"10","author":"Levy R","year":"1990","unstructured":"R Levy, A R Miller J Natl Cancer Inst Monogr 10, 61\u201368 (1990).","journal-title":"J Natl Cancer Inst Monogr"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb44039.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.10.3266"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.6.2188"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.8.2825"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008265313133"},{"key":"e_1_3_3_15_2","first-page":"1927","volume":"92","author":"Coiffier C","year":"1998","unstructured":"C Coiffier, N Haioun, A Ketterer, H Engert, H Tilly, D Ma, P Johnson, A Lister, M Feuring-Buske, J A Radford, et al. 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