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Thalamocortical afferents to \u2212\/\u2212 cortex form irregular patches in layer IV within a poorly defined cortical field, which varies between hemispheres, rather than the stereotypic, whisker-specific, segregated map seen in normal animals. Furthermore, many thalamocortical afferents project abnormally to widely separated cortical targets. Taken together, our findings indicate a loss of identifiable whisker territories in the GAP-43 \u2212\/\u2212 mouse cortex. Here, we present a disrupted somatotopic map phenotype in cortex, in clear contrast to the blurring of boundaries within an ordered whisker map in other barrelless mutants. Our results indicate that GAP-43 expression is critical for the normal establishment of ordered topography in barrel cortex.<\/jats:p>","DOI":"10.1073\/pnas.96.16.9397","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:35:07Z","timestamp":1027679707000},"page":"9397-9402","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":128,"title":["Disrupted cortical map and absence of cortical barrels in growth-associated protein (GAP)-43 knockout mice"],"prefix":"10.1073","volume":"96","author":[{"given":"Donna L.","family":"Maier","sequence":"first","affiliation":[{"name":"Departments of Anatomy and Cell Biology, and Pharmacology, State University of New York Health Science Center, Syracuse, NY 13210; National Cancer Institute\/Frederick Cancer Research and Development Center, Building 539 Room 245, P.O. Box B, Fort Detrick, MD 21702-1201; and Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyamala","family":"Mani","sequence":"additional","affiliation":[{"name":"Departments of Anatomy and Cell Biology, and Pharmacology, State University of New York Health Science Center, Syracuse, NY 13210; National Cancer Institute\/Frederick Cancer Research and Development Center, Building 539 Room 245, P.O. Box B, Fort Detrick, MD 21702-1201; and Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy L.","family":"Donovan","sequence":"additional","affiliation":[{"name":"Departments of Anatomy and Cell Biology, and Pharmacology, State University of New York Health Science Center, Syracuse, NY 13210; National Cancer Institute\/Frederick Cancer Research and Development Center, Building 539 Room 245, P.O. Box B, Fort Detrick, MD 21702-1201; and Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Soppet","sequence":"additional","affiliation":[{"name":"Departments of Anatomy and Cell Biology, and Pharmacology, State University of New York Health Science Center, Syracuse, NY 13210; National Cancer Institute\/Frederick Cancer Research and Development Center, Building 539 Room 245, P.O. Box B, Fort Detrick, MD 21702-1201; and Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lino","family":"Tessarollo","sequence":"additional","affiliation":[{"name":"Departments of Anatomy and Cell Biology, and Pharmacology, State University of New York Health Science Center, Syracuse, NY 13210; National Cancer Institute\/Frederick Cancer Research and Development Center, Building 539 Room 245, P.O. Box B, Fort Detrick, MD 21702-1201; and Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"McCasland","sequence":"additional","affiliation":[{"name":"Departments of Anatomy and Cell Biology, and Pharmacology, State University of New York Health Science Center, Syracuse, NY 13210; National Cancer Institute\/Frederick Cancer Research and Development Center, Building 539 Room 245, P.O. Box B, Fort Detrick, MD 21702-1201; and Human Genome Sciences, 9410 Key West Avenue, Rockville, MD 20850"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina F.","family":"Meiri","sequence":"additional","affiliation":[{"name":"Departments of Anatomy and Cell Biology, and Pharmacology, State University of New York Health Science Center, Syracuse, NY 13210; National Cancer Institute\/Frederick Cancer Research and Development Center, Building 539 Room 245, P.O. 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