{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:09:41Z","timestamp":1792274981024,"version":"4.4.0"},"reference-count":23,"publisher":"National Academy of Sciences","issue":"17","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1999,8,17]]},"abstract":"<jats:p>\n                    The mouse\n                    <jats:italic>Bapx1<\/jats:italic>\n                    gene is homologous to the\n                    <jats:italic>Drosophila<\/jats:italic>\n                    homeobox containing\n                    <jats:italic>bagpipe<\/jats:italic>\n                    (\n                    <jats:italic>bap<\/jats:italic>\n                    ) gene. A shared characteristic of the genes in these two organisms is expression in gut mesoderm. In\n                    <jats:italic>Drosophila, bap<\/jats:italic>\n                    functions to specify the formation of the musculature of the midgut. To determine the function of the mammalian cognate, we targeted a mutation into the\n                    <jats:italic>Bapx1<\/jats:italic>\n                    locus. Bapx1, similar to\n                    <jats:italic>Drosophila<\/jats:italic>\n                    , does have a conspicuous role in gut mesoderm; however, this appears to be restricted to development of the spleen. In addition,\n                    <jats:italic>Bapx1<\/jats:italic>\n                    has a major role in the development of the axial skeleton. Loss of\n                    <jats:italic>Bapx1<\/jats:italic>\n                    affects the distribution of sclerotomal cells, markedly reducing the number that appear ventromedially around the notochord. Subsequently, the structures in the midaxial region, the intervertebral discs, and centra of the vertebral bodies, fail to form. Abnormalities are also found in those bones of the basal skull (basioccipital and basisphenoid bones) associated with the notochord. We postulate that\n                    <jats:italic>Bapx1<\/jats:italic>\n                    confers the capacity of cells to interact with the notochord, effecting inductive interactions essential for development of the vertebral column and chondrocranium.\n                  <\/jats:p>","DOI":"10.1073\/pnas.96.17.9695","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:38:21Z","timestamp":1027679901000},"page":"9695-9700","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":127,"title":["The mouse bagpipe gene controls development of axial skeleton, skull, and spleen"],"prefix":"10.1073","volume":"96","author":[{"given":"Laura A.","family":"Lettice","sequence":"first","affiliation":[{"name":"Medical Research Council\u2013Human Genetics Unit, Western General Hospital, Crewe Road Edinburgh EH4 2XU, United Kingdom; and Fujisawa Institute of Neuroscience, Department of Neuroscience, University of Edinburgh, George Square, Edinburgh EH8 9JZ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorna A.","family":"Purdie","sequence":"additional","affiliation":[{"name":"Medical Research Council\u2013Human Genetics Unit, Western General Hospital, Crewe Road Edinburgh EH4 2XU, United Kingdom; and Fujisawa Institute of Neuroscience, Department of Neuroscience, University of Edinburgh, George Square, Edinburgh EH8 9JZ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey J.","family":"Carlson","sequence":"additional","affiliation":[{"name":"Medical Research Council\u2013Human Genetics Unit, Western General Hospital, Crewe Road Edinburgh EH4 2XU, United Kingdom; and Fujisawa Institute of Neuroscience, Department of Neuroscience, University of Edinburgh, George Square, Edinburgh EH8 9JZ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Kilanowski","sequence":"additional","affiliation":[{"name":"Medical Research Council\u2013Human Genetics Unit, Western General Hospital, Crewe Road Edinburgh EH4 2XU, United Kingdom; and Fujisawa Institute of Neuroscience, Department of Neuroscience, University of Edinburgh, George Square, Edinburgh EH8 9JZ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Dorin","sequence":"additional","affiliation":[{"name":"Medical Research Council\u2013Human Genetics Unit, Western General Hospital, Crewe Road Edinburgh EH4 2XU, United Kingdom; and Fujisawa Institute of Neuroscience, Department of Neuroscience, University of Edinburgh, George Square, Edinburgh EH8 9JZ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Hill","sequence":"additional","affiliation":[{"name":"Medical Research Council\u2013Human Genetics Unit, Western General Hospital, Crewe Road Edinburgh EH4 2XU, United Kingdom; and Fujisawa Institute of Neuroscience, Department of Neuroscience, University of Edinburgh, George Square, Edinburgh EH8 9JZ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1999,8,17]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(97)00067-1"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(97)00520-9"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.20.7716"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.0212"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.8416"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.7.7b.1325"},{"key":"e_1_3_3_7_2","first-page":"2169","volume":"9","author":"Nehls M","year":"1994","unstructured":"M Nehls, D Pfeifer, T Boehm Oncogene 9, 2169\u20132175 (1994).","journal-title":"Oncogene"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/359211a0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/19.15.4293"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(98)00071-9"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/368747a0"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.117.2.409"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.121.9.2909"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.120.5.1109"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.15.8692"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(67)90006-1"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-169X.1993.00001.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.119.3.649"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90009-4"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90008-6"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90398-4"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.1.113"},{"key":"e_1_3_3_23_2","first-page":"129","volume":"7","author":"Balling R","year":"1996","unstructured":"R Balling, A Neubuser, B Christ Cell Dev Biol 7, 129\u2013136 (1996).","journal-title":"Cell Dev Biol"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.96.17.9695","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T16:42:45Z","timestamp":1649868165000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.96.17.9695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,8,17]]},"references-count":23,"journal-issue":{"issue":"17","published-print":{"date-parts":[[1999,8,17]]}},"alternative-id":["10.1073\/pnas.96.17.9695"],"URL":"https:\/\/doi.org\/10.1073\/pnas.96.17.9695","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,8,17]]},"assertion":[{"value":"1998-12-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1999-08-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}