{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:31:46Z","timestamp":1791498706589,"version":"4.3.4"},"reference-count":67,"publisher":"National Academy of Sciences","issue":"17","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1999,8,17]]},"abstract":"<jats:p>\n                    AIDS-related non-Hodgkin\u2019s lymphoma (AIDS NHL) comprises a diverse and heterogeneous group of high-grade B cell tumors. Certain classes of AIDS NHL are associated with alterations in oncogenes or tumor-suppressor genes or infections by oncogenic herpesviruses. However, the clinically significant class of AIDS NHL designated immunoblastic lymphoma plasmacytoid (AIDS IBLP) lacks any consistent genetic alterations. We identified the\n                    <jats:italic>TCL1<\/jats:italic>\n                    oncogene from a set of AIDS IBLP-associated cDNA fragments generated by subtractive hybridization with non-AIDS IBLP. Aberrant\n                    <jats:italic>TCL1<\/jats:italic>\n                    expression has been implicated in T cell leukemia\/lymphoma development, and its expression also has been seen in many established B cell tumor lines. However,\n                    <jats:italic>TCL1<\/jats:italic>\n                    expression has not been reported in AIDS NHL. We find that\n                    <jats:italic>TCL1<\/jats:italic>\n                    is expressed in the majority of AIDS IBLP tumors examined. TCL1 protein expression is restricted to tumor cells in AIDS IBLP tissue samples analyzed with immunohistochemical staining. Hyperplastic lymph node and tonsil also exhibit strong TCL1 protein expression in mantle zone B cells and in rare interfollicular zone cells, whereas follicle-center B cells (centroblasts and centrocytes) show weaker expression. These results establish\n                    <jats:italic>TCL1<\/jats:italic>\n                    as the most prevalent of all of the surveyed oncogenes associated with AIDS IBLP. They also indicate that abundant TCL1 expression in quiescent mantle zone B cells is down-regulated in activated germinal center follicular B cells in parallel to the known expression pattern of BCL-2. High-level expression in nonproliferating B cells suggests that TCL1 may function in protecting na\u00efve preactivated B cells from apoptosis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.96.17.9809","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:38:21Z","timestamp":1027679901000},"page":"9809-9814","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":65,"title":["TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues"],"prefix":"10.1073","volume":"96","author":[{"given":"Michael","family":"Teitell","sequence":"first","affiliation":[{"name":"Molecular Biology Institute, Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, Department of Pediatrics, Division of Hematology\/Oncology, Gwynne Hazen Cherry Memorial Laboratories, and Department of Microbiology and Immunology, University of California, Los Angeles School of Medicine, Los 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