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Here we show that\n                    <jats:italic>ku86-<\/jats:italic>\n                    mutant mice, compared with control littermates, prematurely exhibited age-specific changes characteristic of senescence that include osteopenia, atrophic skin, hepatocellular degeneration, hepatocellular inclusions, hepatic hyperplastic foci, and age-specific mortality. Cancer and likely sepsis (indicated by reactive immune responses) partly contributed to age-specific mortality for both cohorts, and both conditions occurred earlier in\n                    <jats:italic>ku86<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. These data indicate that Ku86-dependent chromosomal metabolism is important for determining the onset of age-specific changes characteristic of senescence in mice.\n                  <\/jats:p>","DOI":"10.1073\/pnas.96.19.10770","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:38:21Z","timestamp":1027679901000},"page":"10770-10775","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":316,"title":["Deletion of Ku86 causes early onset of senescence in mice"],"prefix":"10.1073","volume":"96","author":[{"given":"Hannes","family":"Vogel","sequence":"first","affiliation":[{"name":"Department of Pathology and Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX 77030; and Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381-4287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-Sik","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Pathology and Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX 77030; and Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381-4287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Karsenty","sequence":"additional","affiliation":[{"name":"Department of Pathology and Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX 77030; and Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381-4287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton","family":"Finegold","sequence":"additional","affiliation":[{"name":"Department of Pathology and Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX 77030; and Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381-4287"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Hasty","sequence":"additional","affiliation":[{"name":"Department of Pathology and Department of Human and Molecular Genetics, Baylor College of Medicine, Houston, TX 77030; and Lexicon Genetics, 4000 Research Forest Drive, The Woodlands, TX 77381-4287"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1999,9,14]]},"reference":[{"key":"e_1_3_3_1_2","first-page":"5","volume":"14","author":"Martin G M","year":"1978","unstructured":"G M Martin Birth Defects Orig Artic Ser 14, 5\u201339 (1978).","journal-title":"Birth Defects Orig Artic Ser"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196605000-00001"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5259.258"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0997-100"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/2410"},{"key":"e_1_3_3_6_2","unstructured":"Martin G. 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