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Here, we report that BN 80933 [(\n                    <jats:italic>S<\/jats:italic>\n                    )-\n                    <jats:italic>N<\/jats:italic>\n                    -{4-[4-[(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2\n                    <jats:italic>H<\/jats:italic>\n                    -1-benzopyran-2-yl)carbonyl]-1-piperazinyl]phenyl}-2-thiophenecarboximidamide], a compound that combines potent antioxidant and selective nNOS inhibitory properties\n                    <jats:italic>in vitro<\/jats:italic>\n                    , affords remarkable neuronal protection\n                    <jats:italic>in vivo<\/jats:italic>\n                    . Intravenous administration of BN 80933 significantly reduced brain damage induced by head trauma in mice, global ischemia in gerbils, and transient focal ischemia in rats. Treatment with BN 80933 (0.3\u201310 mg\/kg) significantly reduced infarct volume (&gt;60% protection) and enhanced behavioral recovery in rats subjected to transient (2-h) middle cerebral artery occlusion and 48-h or 7-day reperfusion. Furthermore, treatment with BN 80933 commencing up to 8 h after the onset of ischemia resulted in a significant improvement of neurological outcome. All these results indicate that BN 80933 represents a class of potentially useful therapeutic agents for the treatment of stroke or trauma and possibly neurodegenerative disorders that involve both NO and ROS.\n                  <\/jats:p>","DOI":"10.1073\/pnas.96.19.10824","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:38:21Z","timestamp":1027679901000},"page":"10824-10829","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":108,"title":["BN 80933, a dual inhibitor of neuronal nitric oxide synthase and lipid peroxidation: A promising neuroprotective strategy"],"prefix":"10.1073","volume":"96","author":[{"given":"Pierre-Etienne","family":"Chabrier","sequence":"first","affiliation":[{"name":"Beaufour-Ipsen Research Laboratories, Institut Henri Beaufour, 5 Avenue du Canada, 91966 Les Ulis Cedex, France; and Wolfson Institute for Biomedical Research, University College London, Tottenham Court 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