{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:35:55Z","timestamp":1792668955179,"version":"4.5.0"},"reference-count":35,"publisher":"National Academy of Sciences","issue":"2","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1999,1,19]]},"abstract":"<jats:p>\n                    In human cells, efficient global genomic repair of DNA damage induced by ultraviolet radiation requires the p53 tumor suppressor, but the mechanism has been unclear. The\n                    <jats:italic>p48<\/jats:italic>\n                    gene is required for expression of an ultraviolet radiation-damaged DNA binding activity and is disrupted by mutations in the subset of xeroderma pigmentosum group E cells that lack this activity. Here, we show that\n                    <jats:italic>p48<\/jats:italic>\n                    mRNA levels strongly depend on basal p53 expression and increase further after DNA damage in a p53-dependent manner. Furthermore, like p53\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    cells, xeroderma pigmentosum group E cells are deficient in global genomic repair. These results identify p48 as the link between p53 and the nucleotide excision repair apparatus.\n                  <\/jats:p>","DOI":"10.1073\/pnas.96.2.424","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:39:15Z","timestamp":1027679955000},"page":"424-428","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":461,"title":["Expression of the\n                    <i>p48<\/i>\n                    xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair"],"prefix":"10.1073","volume":"96","author":[{"given":"Byung Joon","family":"Hwang","sequence":"first","affiliation":[{"name":"Departments of Medicine and Biochemistry and Department of Biological Sciences, Stanford University School of Medicine, Stanford, CA 94305-5115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Ford","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Biochemistry and Department of Biological Sciences, Stanford University School of Medicine, Stanford, CA 94305-5115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip C.","family":"Hanawalt","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Biochemistry and Department of Biological Sciences, Stanford University School of Medicine, Stanford, CA 94305-5115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Chu","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Biochemistry and Department of Biological Sciences, Stanford University School of Medicine, Stanford, CA 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