{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:26:05Z","timestamp":1791293165367,"version":"4.1.0"},"reference-count":55,"publisher":"National Academy of Sciences","issue":"20","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1999,9,28]]},"abstract":"<jats:p>\n                    Galectin-7 is a \u03b2-galactoside binding protein specifically expressed in stratified epithelia and notably in epidermis, but barely detectable in epidermal tumors and absent from squamous carcinoma cell lines. Galectin-7 gene is an early transcriptional target of the tumor suppressor protein P53 [Polyak, K., Xia, Y., Zweier, J., Kinzler, K. &amp; Vogelstein, B. (1997)\n                    <jats:italic>Nature (London)<\/jats:italic>\n                    389, 300\u2013305]. Because p53 transcriptional activity is increased by genotoxic stresses we have examined the possible effects of ultraviolet radiations (UVB) on galectin-7 expression in epidermal keratinocytes. The amounts of galectin-7 mRNA and protein are increased rapidly after UVB irradiation of epidermal keratinocytes. The increase of galectin-7 is parallel to P53 stabilization. UVB irradiation of skin reconstructed\n                    <jats:italic>in vitro<\/jats:italic>\n                    and of human skin\n                    <jats:italic>ex vivo<\/jats:italic>\n                    demonstrates that galectin-7 overexpression is associated with sunburn\/apoptotic keratinocytes. Transfection of a galectin-7 expression vector results in a significant increase in terminal deoxynucleotidyltransferase-mediated UTP end labeling-positive keratinocytes. The present findings demonstrate a keratinocyte-specific protein involved in the UV-induced apoptosis, an essential process in the maintenance of epidermal homeostasis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.96.20.11329","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:31:44Z","timestamp":1027679504000},"page":"11329-11334","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":166,"title":["Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes"],"prefix":"10.1073","volume":"96","author":[{"given":"Francoise","family":"Bernerd","sequence":"first","affiliation":[{"name":"L\u2019Or\u00e9al, Centre de Recherche Charles Zviak, 90 rue du G\u00e9n\u00e9ral Roguet, 92583 Clichy Cedex, France; and Laboratoire de G\u00e9n\u00e9tique Mol\u00e9culaire, Centre National de la Recherche Scientifique UPR42, 7 rue Guy Moquet, BP8, 94801 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Sarasin","sequence":"additional","affiliation":[{"name":"L\u2019Or\u00e9al, Centre de Recherche Charles Zviak, 90 rue du G\u00e9n\u00e9ral Roguet, 92583 Clichy Cedex, France; and Laboratoire de G\u00e9n\u00e9tique Mol\u00e9culaire, Centre National de la Recherche Scientifique UPR42, 7 rue Guy Moquet, BP8, 94801 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Magnaldo","sequence":"additional","affiliation":[{"name":"L\u2019Or\u00e9al, Centre de Recherche Charles Zviak, 90 rue du G\u00e9n\u00e9ral Roguet, 92583 Clichy Cedex, France; and Laboratoire de G\u00e9n\u00e9tique Mol\u00e9culaire, Centre National de la Recherche Scientifique UPR42, 7 rue Guy Moquet, BP8, 94801 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1999,9,28]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0955-0674(90)90152-5"},{"key":"e_1_3_3_2_2","first-page":"169","volume-title":"Cancer Cells 1: The Transformed Phenotype","author":"Sun T","year":"1984","unstructured":"T Sun, R Eichner, A Schermer, D Cooper, W Nelson, R Weiss Cancer Cells 1: The Transformed Phenotype, eds A J Levine, G F Van de Woude, W Topp, J D Watson (Cold Spring Harbor Lab. 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