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We expressed and purified the proteins encoded by the MC53L and MC54L genes of MCV, as well as their human and murine homologs. All four recombinant proteins were able to bind with high affinity to human and murine IL-18 molecules and inhibited IL-18 mediated interferon \u03b3 production in a dose-dependent manner. The pirating of IL-18 binding proteins by poxviruses and their use as decoy receptors is consistent with the critical role of IL-18 in defense against virus infections and provides a mechanism for evasion of the immune system by MCV.<\/jats:p>","DOI":"10.1073\/pnas.96.20.11537","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:41:48Z","timestamp":1027680108000},"page":"11537-11542","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":165,"title":["IL-18 binding and inhibition of interferon \u03b3 induction by human poxvirus-encoded proteins"],"prefix":"10.1073","volume":"96","author":[{"given":"Yan","family":"Xiang","sequence":"first","affiliation":[{"name":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0445"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Moss","sequence":"additional","affiliation":[{"name":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0445"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1999,9,28]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1994.tb02853.x"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/314620"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-198906000-00009"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1996.0631"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1995.0037"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5276.813"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1997.8607"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.18.9875"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6403"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1998.9390"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5347.102"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.4.1172"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/386517a0"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.15.9621"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80013-8"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)00148-9"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1999.9676"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.57.2.590-595.1989"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70518-X"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80543-9"},{"key":"e_1_3_3_21_2","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.4049\/jimmunol.156.11.4274","volume":"156","author":"Ushio S","year":"1996","unstructured":"S Ushio, M Namba, T Okura, K Hattori, Y Nukada, K Akita, F Tanabe, K Konishi, M Micallef, M Fujii, et al. 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