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Here we demonstrate LCMV-WE persistence at low levels after infection with 10\n                    <jats:sup>2<\/jats:sup>\n                    or 10\n                    <jats:sup>6<\/jats:sup>\n                    plaque-forming units, shown as viral genome, viral antigen, and replicative virus using sensitive\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo<\/jats:italic>\n                    assays. The finding that LCMV-WE persists in the face of apparently intact immune responses resembles the situation in some viral (hepatitis B and C, HIV) and bacterial (tuberculosis, leprosy) infections in humans; the results are relevant to the understanding not only of other murine and human persistent viral infections but also of protective immunological memory by \u201cinfection immunity.\u201d\n                  <\/jats:p>","DOI":"10.1073\/pnas.96.21.11964","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:38:21Z","timestamp":1027679901000},"page":"11964-11969","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":90,"title":["Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice"],"prefix":"10.1073","volume":"96","author":[{"given":"Adrian","family":"Ciurea","sequence":"first","affiliation":[{"name":"Institute for Experimental Immunology, Department of Pathology, 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