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In contrast to normal mice, the CREM-deficient mice show equal locomotor activity during the circadian cycle. The anatomy of the hypothalamic suprachiasmatic nuclei, the center of the endogenous pacemaker, is normal in mutant mice. Remarkably, CREM mutant mice also elicit a different emotional state, revealed by a lower anxiety in two different behavioral models, but they preserve the conditioned reactiveness to stress. These results demonstrate the high degree of functional specificity of each cAMP-responsive transcription factor in behavioral control.<\/jats:p>","DOI":"10.1073\/pnas.96.24.14094","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:40:52Z","timestamp":1027680052000},"page":"14094-14099","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":61,"title":["Altered emotional and locomotor responses in mice deficient in the transcription factor CREM"],"prefix":"10.1073","volume":"96","author":[{"given":"Rafael","family":"Maldonado","sequence":"first","affiliation":[{"name":"D\u00e9partement de Pharmacologie Mol\u00e9culaire et Structurale, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U266, Centre Nationale de la Recherche Scientifique, Unit\u00e9 de la Recherche Associ\u00e9e D1500, Universit\u00e9 Ren\u00e9 Descartes, 75270 Paris, France; and Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Centre Nationale de la Recherche Scientifique, Universit\u00e9 Louis Pasteur, BP 163, 67404 Illkirch, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Smadja","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie Mol\u00e9culaire et Structurale, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U266, Centre Nationale de la Recherche Scientifique, Unit\u00e9 de la Recherche Associ\u00e9e D1500, Universit\u00e9 Ren\u00e9 Descartes, 75270 Paris, France; and Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Centre Nationale de la Recherche Scientifique, Universit\u00e9 Louis Pasteur, BP 163, 67404 Illkirch, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Mazucchelli","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie Mol\u00e9culaire et Structurale, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U266, Centre Nationale de la Recherche Scientifique, Unit\u00e9 de la Recherche Associ\u00e9e D1500, Universit\u00e9 Ren\u00e9 Descartes, 75270 Paris, France; and Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Centre Nationale de la Recherche Scientifique, Universit\u00e9 Louis Pasteur, BP 163, 67404 Illkirch, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Sassone-Corsi","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie Mol\u00e9culaire et Structurale, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U266, Centre Nationale de la Recherche Scientifique, Unit\u00e9 de la Recherche Associ\u00e9e D1500, Universit\u00e9 Ren\u00e9 Descartes, 75270 Paris, France; and Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Centre Nationale de la Recherche Scientifique, Universit\u00e9 Louis Pasteur, BP 163, 67404 Illkirch, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1999,11,23]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cb.11.110195.002035"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.66.1.807"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90532-U"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/365314a0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/381083a0"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.184.4144.1341"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.14140"},{"key":"e_1_3_3_8_2","volume-title":"The Mind\u2019s Clock","author":"Klein D C","year":"1991","unstructured":"D C Klein, R Y Moore, S M Reppert The Mind\u2019s Clock (Oxford Univ. 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