{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:01:02Z","timestamp":1781107262619,"version":"3.54.1"},"reference-count":42,"publisher":"National Academy of Sciences","issue":"3","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1999,2,2]]},"abstract":"<jats:p>\n                    By screening for mutations that perturb the invagination of the vulva of the\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    hermaphrodite, we have isolated 25 mutations that define eight genes. We have named these genes\n                    <jats:italic>sqv-1<\/jats:italic>\n                    to\n                    <jats:italic>sqv-8<\/jats:italic>\n                    (squashed vulva). All 25 mutations cause the same vulval defect, an apparent partial collapse of the vulval invagination and an elongation of the central vulval cells. Most\n                    <jats:italic>sqv<\/jats:italic>\n                    mutations also cause an oocyte or somatic gonad defect that results in hermaphrodite sterility, and some\n                    <jats:italic>sqv<\/jats:italic>\n                    mutations cause maternal-effect lethality. We propose that the\n                    <jats:italic>sqv<\/jats:italic>\n                    genes affect a pathway common to vulval invagination, oocyte development, and embryogenesis.\n                  <\/jats:p>","DOI":"10.1073\/pnas.96.3.968","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:35:07Z","timestamp":1027679707000},"page":"968-973","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":110,"title":["<i>sqv<\/i>\n                    mutants of\n                    <i>Caenorhabditis elegans<\/i>\n                    are defective in vulval epithelial invagination"],"prefix":"10.1073","volume":"96","author":[{"given":"Tory","family":"Herman","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Room 68-425, 77 Massachusetts Avenue, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Hartwieg","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Room 68-425, 77 Massachusetts Avenue, Cambridge, MA 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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