{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:25:37Z","timestamp":1791300337065,"version":"4.1.0"},"reference-count":32,"publisher":"National Academy of Sciences","issue":"4","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1999,2,16]]},"abstract":"<jats:p>After a primary infection, herpes simplex virus is maintained in a\n latent state in neurons of sensory ganglia until complex stimuli\n reactivate viral lytic replication. Although the mechanisms governing\n reactivation from the latent state remain unknown, the regulated\n expression of the viral immediate early genes represents a critical\n point in this process. These genes are controlled by transcription\n enhancer complexes whose assembly requires and is coordinated by the\n cellular C1 factor (host cell factor). In contrast to other tissues,\n the C1 factor is not detected in the nuclei of sensory neurons.\n Experimental conditions that induce the reactivation of herpes simplex\n virus in mouse model systems result in rapid nuclear localization of\n the protein, indicating that the C1 factor is sequestered in these\n cells until reactivation signals induce a redistribution of the\n protein. The regulated localization suggests that C1 is a critical\n switch determinant of the viral lytic\u2013latent cycle.<\/jats:p>","DOI":"10.1073\/pnas.96.4.1229","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:40:52Z","timestamp":1027680052000},"page":"1229-1233","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":106,"title":["Nuclear localization of the C1 factor (host cell factor) in sensory neurons correlates with reactivation of herpes simplex virus from latency"],"prefix":"10.1073","volume":"96","author":[{"given":"Thomas M.","family":"Kristie","sequence":"first","affiliation":[{"name":"Laboratory of Viral Diseases, National Institutes of\r Health, Building 4-133, 9000, Rockville Pike, Bethesda, MD 20892; and\r Department of Microbiology and Immunology, Emory University,\r #3127, 1510 Clifton Avenue, Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi 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