{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:32:53Z","timestamp":1790937173600,"version":"4.1.0"},"reference-count":45,"publisher":"National Academy of Sciences","issue":"4","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1999,2,16]]},"abstract":"<jats:p>\n                    Peroxisome proliferator-activated receptors (PPARs) are\n ligand-dependent transcription factors, and it is assumed that the\n biological effects of these receptors depend on interactions with\n recently identified coactivators, including steroid receptor\n coactivator-1 (SRC-1). We assessed the\n                    <jats:italic>in vivo<\/jats:italic>\n                    function\n of SRC-1 on the PPAR\u03b1-regulated gene expression in liver by\n generating mice in which the SRC-1 gene was inactivated by gene\n targeting. The homozygous (SRC-1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) mice were viable and\n fertile and exhibited no detectable gross phenotypic defects. When\n challenged with a PPAR\u03b1 ligand, such as ciprofibrate or Wy-14,643,\n the SRC-1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice displayed typical pleiotropic\n responses, including hepatomegaly, peroxisome proliferation in\n hepatocytes, and increased mRNA and protein levels of genes that are\n regulated by PPAR\u03b1. These alterations were indistinguishable from\n those exhibited by SRC-1\n                    <jats:sup>+\/+<\/jats:sup>\n                    wild-type mice fed either\n ciprofibrate- or Wy-14,643-containing diets. These results indicate\n that SRC-1 is not essential for PPAR\u03b1-mediated transcriptional\n activation\n                    <jats:italic>in vivo<\/jats:italic>\n                    and suggest redundancy in\n nuclear receptor coactivators.\n                  <\/jats:p>","DOI":"10.1073\/pnas.96.4.1585","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:42:40Z","timestamp":1027680160000},"page":"1585-1590","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":61,"title":["Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor \u03b1-regulated gene expression"],"prefix":"10.1073","volume":"96","author":[{"given":"Chao","family":"Qi","sequence":"first","affiliation":[{"name":"Department of Pathology, Northwestern University Medical School,\r Chicago, IL 60611; and Department of Pathology, University of\r North Carolina, Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University Medical School,\r Chicago, IL 60611; and Department of Pathology, University of\r North Carolina, Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University Medical School,\r Chicago, IL 60611; and Department of Pathology, University of\r North Carolina, Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjana V.","family":"Yeldandi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University Medical School,\r Chicago, IL 60611; and Department of Pathology, University of\r North Carolina, Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Sambasiva","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University Medical School,\r Chicago, IL 60611; and Department of Pathology, University of\r North Carolina, Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyo","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University Medical School,\r Chicago, IL 60611; and Department of Pathology, University of\r North Carolina, Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Subbarao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University Medical School,\r Chicago, IL 60611; and Department of Pathology, University of\r North Carolina, Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujata","family":"Pulikuri","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University Medical School,\r Chicago, IL 60611; and Department of Pathology, University of\r North Carolina, Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University Medical School,\r Chicago, IL 60611; and Department of Pathology, University of\r North Carolina, Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janardan K.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Pathology, Northwestern University Medical School,\r Chicago, IL 60611; and Department of Pathology, University of\r North Carolina, Chapel Hill, NC 27599"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1999,2,16]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198095"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb18616.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/347645a0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.15.6.3012"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)74184-2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.10.1224"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.1.8536636"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65577-0"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/358771a0"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/283397a0"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.25.15639"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/2036"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/2042"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/383022a0"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(97)80066-X"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5240.1354"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00736.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.10.4948"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80516-4"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5328.965"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/42652"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.16.8479"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81118-6"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.20.10626"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.41.25500"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.14.7939"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81410-5"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.11.5517"},{"key":"e_1_3_3_29_2","first-page":"185","volume":"6","author":"Zhu Y","year":"1996","unstructured":"Y Zhu, C Qi, C Calandra, M S Rao, J K Reddy Gene Expression 6, 185\u2013195 (1996).","journal-title":"Gene Expression"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.40.24698"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.13.6731"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.10.5678"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/42750"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.7.2927"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90199-X"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)82001-2"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/38304"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.52.33435"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7602"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/25931"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.27.16114"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/1990"},{"key":"e_1_3_3_43_2","volume-title":"Cell Biochem. 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