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Surprisingly, as the resulting immortalized cells containing active telomerase continue to proliferate, their telomeres continue to shorten to mean lengths below those in control cells that enter crisis. These results provide evidence for a protective function of human telomerase that allows cell proliferation without requiring net lengthening of telomeres.<\/jats:p>","DOI":"10.1073\/pnas.96.7.3723","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:39:15Z","timestamp":1027679955000},"page":"3723-3728","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":296,"title":["Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening"],"prefix":"10.1073","volume":"96","author":[{"given":"Jiyue","family":"Zhu","sequence":"first","affiliation":[{"name":"The G. W. 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