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In early KS, HHV-8 is present in &lt;10% of cells forming the walls of ectatic vessels. In nodular KS, HHV-8 is present in cells surrounding slit-like vessels and in &gt;90% of spindle cells, but not in normal vascular endothelium. In addition, HHV-8 colocalizes with vascular endothelial growth factor receptor-3 (VEGFR-3), a marker of lymphatic and precursor endothelium. In early KS lesions, VEGFR-3 is more extensively expressed than LNA-1, indicating that HHV-8 is not inducing the proliferation of VEGFR-3-positive endothelium directly. In MCD, HHV-8 is present in mantle zone large immunoblastic B cells. No staining for LNA-1 is seen in samples from multiple myeloma, prostate cancer, and angiosarcoma, supporting the absence of any etiological link between these diseases and HHV-8.<\/jats:p>","DOI":"10.1073\/pnas.96.8.4546","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:39:15Z","timestamp":1027679955000},"page":"4546-4551","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":581,"title":["Distribution of human herpesvirus-8 latently infected cells in Kaposi\u2019s sarcoma, multicentric Castleman\u2019s disease, and primary effusion lymphoma"],"prefix":"10.1073","volume":"96","author":[{"given":"Nicolas","family":"Dupin","sequence":"first","affiliation":[{"name":"Departments of Oncology and Molecular Pathology, Royal Free and University College Medical School, UCL, London, United Kingdom W1P 6BT; Department of Pathology, Royal Marsden NHS Trust, London, United Kingdom SW3 6JB; Department of Oncology and Pathology, Soroka Medical Center and Ben Gurion University of the Negev, Beer Sheva, Israel 84105; 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