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This instrumentation, along with the use of a biocompatible charcoal oximetry-probe suspension, enabled 3D spatial imaging of the gastrointestinal (GI) tract, along with mapping of oxygenation in living mice. By using these techniques, the oxygen tension was mapped at different levels of the GI tract from the stomach to the rectum. The results clearly show the presence of a marked oxygen gradient from the proximal to the distal GI tract, which decreases after respiratory arrest. This technique for\n                    <jats:italic>in vivo<\/jats:italic>\n                    mapping of oxygenation is a promising method, enabling the noninvasive imaging of oxygen within the normal GI tract. This method should be useful in determining the alterations in oxygenation associated with disease.\n                  <\/jats:p>","DOI":"10.1073\/pnas.96.8.4586","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:39:15Z","timestamp":1027679955000},"page":"4586-4591","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":368,"title":["Noninvasive measurement of anatomic structure and intraluminal oxygenation in the gastrointestinal tract of living mice with spatial and spectral EPR imaging"],"prefix":"10.1073","volume":"96","author":[{"given":"Guanglong","family":"He","sequence":"first","affiliation":[{"name":"Molecular and Cellular Biophysics Laboratories, Department of Medicine, Division of Cardiology and the EPR Center, Johns Hopkins Medical Institutions, 5501 Hopkins Bayview Circle, Baltimore, MD 21224"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi 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