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Although some Blmh null mice were viable and reproduced, only about 65% of the expected number survived the neonatal period, revealing an important role for Blmh in neonatal survival. Mice lacking Blmh exhibited variably penetrant tail dermatitis that resembled rodent ringtail. The histopathology of the tail dermatitis was similar to skin lesions in humans with pellagra, necrolytic migratory erythema, and acrodermatitis enteropathica. Compared with controls, Blmh null mice were more sensitive to acute BLM lethality and developed pulmonary fibrosis more readily following BLM treatment. Thus, we have established that Blmh is an essential protectant against BLM-induced death and has an important role in neonatal survival and in maintaining epidermal integrity.\n                  <\/jats:p>","DOI":"10.1073\/pnas.96.8.4680","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:39:15Z","timestamp":1027679955000},"page":"4680-4685","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":92,"title":["The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance"],"prefix":"10.1073","volume":"96","author":[{"given":"Donald R.","family":"Schwartz","sequence":"first","affiliation":[{"name":"Departments of Pharmacology, Anesthesiology\/Critical Care Medicine, and Pathology, and Division of Laboratory Animal Resources, University of Pittsburgh, Pittsburgh, PA 15261"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg 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