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Many of the channel diseases are\n \u201cparoxysmal disorders\u201d whose principal symptoms occur\n intermittently in individuals who otherwise may be healthy and active.\n Some of the ion channels that cause human neurological disease are old\n acquaintances previously cloned and extensively studied by channel\n specialists. In other cases, however, disease-gene hunts have led the\n way to the identification of new channel genes. Progress in the study\n of ion channels has made it possible to analyze the effects of human\n neurological disease-causing channel mutations at the level of the\n single channel, the subcellular domain, the neuronal network, and the\n behaving organism.<\/jats:p>","DOI":"10.1073\/pnas.96.9.4759","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:35:50Z","timestamp":1027679750000},"page":"4759-4766","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":119,"title":["Ion channel genes and human neurological disease: Recent progress, prospects, and challenges"],"prefix":"10.1073","volume":"96","author":[{"given":"Edward C.","family":"Cooper","sequence":"first","affiliation":[{"name":"Departments of Neurology, and Physiology, Biochemistry,\r and Howard Hughes Medical Institute, University of California, San\r Francisco, CA 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily Yeh","family":"Jan","sequence":"additional","affiliation":[{"name":"Departments of Neurology, and Physiology, Biochemistry,\r and Howard Hughes Medical Institute, University of California, San\r Francisco, CA 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1999,4,27]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0198-53"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0198-25"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5349.403"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.3.479"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/1252"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5395.1890"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/25367"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80556-5"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-18-07200.1998"},{"key":"e_1_3_3_10_2","unstructured":"Zhang C.-L. 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