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Secretion of some Yops requires the assistance, in the bacterial cytosol, of small individual chaperones called the Syc proteins. These chaperones act as bodyguards or secretion pilots for their partner Yop. Yop proteins fall into two categories. Some are intracellular effectors, whereas the others are \u201ctranslocators\u201d needed to deliver the effectors across the eukaryotic plasma membrane, into eukaryotic cells. The translocators (YopB, YopD, LcrV) form a pore of 16\u201323 \u212b in the eukaryotic cell plasma membrane. The effector Yops are YopE, YopH, YpkA\/YopO, YopP\/YopJ, YopM, and YopT. YopH is a powerful phosphotyrosine phosphatase playing an antiphagocytic role by dephosphorylating several focal adhesion proteins. YopE and YopT contribute to antiphagocytic effects by inactivating GTPases controlling cytoskeleton dynamics. YopP\/YopJ plays an anti-inflammatory role by preventing the activation of the transcription factor NF-\u03baB. It also induces rapid apoptosis of macrophages. 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