{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:57:36Z","timestamp":1791107856422,"version":"4.1.0"},"reference-count":39,"publisher":"National Academy of Sciences","issue":"24","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2000,11,21]]},"abstract":"<jats:p>\n                    Although extracellular application of lysophosphatidic acid (LPA)\n has been extensively documented to produce a variety of cellular\n responses through a family of specific G protein-coupled receptors, the\n                    <jats:italic>in vivo<\/jats:italic>\n                    organismal role of LPA signaling remains largely\n unknown. The first identified LPA receptor gene,\n                    <jats:italic>lp<\/jats:italic>\n                    <jats:sub>A1<\/jats:sub>\n                    \/\n                    <jats:italic>vzg-1<\/jats:italic>\n                    \/\n                    <jats:italic>edg-2<\/jats:italic>\n                    ,\n was previously shown to have remarkably enriched embryonic expression\n in the cerebral cortex and dorsal olfactory bulb and postnatal\n expression in myelinating glia including Schwann cells. Here, we show\n that targeted deletion of\n                    <jats:italic>lp<\/jats:italic>\n                    <jats:sub>A1<\/jats:sub>\n                    results in\n approximately 50% neonatal lethality, impaired suckling in neonatal\n pups, and loss of LPA responsivity in embryonic cerebral cortical\n neuroblasts with survivors showing reduced size, craniofacial\n dysmorphism, and increased apoptosis in sciatic nerve Schwann\n cells. The suckling defect was responsible for the death among\n                    <jats:italic>lp<\/jats:italic>\n                    <jats:sub>A1<\/jats:sub>\n                    <jats:sup>(\u2212\/\u2212)<\/jats:sup>\n                    neonates and the\n stunted growth of survivors. Impaired suckling behavior was\n attributable to defective olfaction, which is likely related to\n developmental abnormalities in olfactory bulb and\/or cerebral cortex.\n Our results provide evidence that endogenous\n lysophospholipid signaling requires an\n                    <jats:italic>lp<\/jats:italic>\n                    receptor gene\n and indicate that LPA signaling through the LP\n                    <jats:sub>A1<\/jats:sub>\n                    receptor\n is required for normal development of an inborn, neonatal behavior.\n                  <\/jats:p>","DOI":"10.1073\/pnas.97.24.13384","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:41:48Z","timestamp":1027680108000},"page":"13384-13389","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":424,"title":["Requirement for the\n                    <i>lp<\/i>\n                    <sub>A1<\/sub>\n                    lysophosphatidic acid receptor gene in normal suckling behavior"],"prefix":"10.1073","volume":"97","author":[{"given":"James J. A.","family":"Contos","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Neuroscience Graduate\r Program, Biomedical Sciences Program, School of Medicine,\r University of California, San Diego, La Jolla, CA 92093-0636"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Neuroscience Graduate\r Program, Biomedical Sciences Program, School of Medicine,\r University of California, San Diego, La Jolla, CA 92093-0636"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua A.","family":"Weiner","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Neuroscience Graduate\r Program, Biomedical Sciences Program, School of Medicine,\r University of California, San Diego, La Jolla, CA 92093-0636"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhruv","family":"Kaushal","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Neuroscience Graduate\r Program, Biomedical Sciences Program, School of Medicine,\r University of California, San Diego, La Jolla, CA 92093-0636"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerold","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Neuroscience Graduate\r Program, Biomedical Sciences Program, School of Medicine,\r University of California, San Diego, La Jolla, CA 92093-0636"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2000,11,21]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90868-4"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90163-7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2910677"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a021681"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(97)80059-2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.65.3.341"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.135.4.1071"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19980907)398:4<587::AID-CNE10>3.0.CO;2-5"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02738068"},{"key":"e_1_3_3_10_2","unstructured":"Contos J. J. A. Ishii I. & Chun J. (2000) Mol.\n Pharmacol. in press."},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.11.6151"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.3.1506"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(98)00589-7"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-04-01371.1999"},{"key":"e_1_3_3_15_2","unstructured":"Fukushima N. Weiner J. A. & Chun J. (2000) Devel.\n Biol. in press."},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.9.5233"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1998.5400"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118634"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2000.6122"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.2144\/97233st02"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.122.4.1165"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.14.7906"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.58.5.895"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.39.27776"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj3300605"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.279.5356.1552"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1089\/152581699319795"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81661-X"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI806"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199709)56:3<177::AID-TERA1>3.0.CO;2-Z"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(87)90042-4"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80200-7"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80435-3"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6997992"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1159\/000113336"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.25.14367"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/347762a0"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90067-5"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.34.22105"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.97.24.13384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T17:15:23Z","timestamp":1649870123000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.97.24.13384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11,21]]},"references-count":39,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2000,11,21]]}},"alternative-id":["10.1073\/pnas.97.24.13384"],"URL":"https:\/\/doi.org\/10.1073\/pnas.97.24.13384","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,11,21]]},"assertion":[{"value":"1999-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-11-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}