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We show\n that the\n                    <jats:italic>STE20a<\/jats:italic>\n                    gene cosegregates with the MATa mating\n type in genetic crosses, maps within the mating-type locus on a 1.8-Mb\n chromosome, and is allelic with the MAT\u03b1 locus. We identify the first\n MATa isolate of the most common pathogenic variety of\n                    <jats:italic>C.\n neoformans<\/jats:italic>\n                    (serotype A, variety\n                    <jats:italic>grubii<\/jats:italic>\n                    ) which\n had been thought to be extinct. This serotype A MATa strain is sterile,\n fails to produce mating pheromone, and is less virulent than a serotype\n A MAT\u03b1 strain in an animal model. Our studies illustrate an\n association of mating type with virulence and suggest that, like\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    , pathogenic isolates of\n                    <jats:italic>C.\n neoformans<\/jats:italic>\n                    may be largely asexual.\n                  <\/jats:p>","DOI":"10.1073\/pnas.97.26.14455","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:44:19Z","timestamp":1027680259000},"page":"14455-14460","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":123,"title":["Identification of the MATa mating-type locus of\n                    <i>Cryptococcus neoformans<\/i>\n                    reveals a serotype A MATa strain thought to have been extinct"],"prefix":"10.1073","volume":"97","author":[{"given":"Klaus B.","family":"Lengeler","sequence":"first","affiliation":[{"name":"Departments of Genetics, Medicine,\r Microbiology, and Pharmacology and Cancer\r Biology, and Howard Hughes Medical Institute, Duke\r University Medical Center, Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Departments of Genetics, Medicine,\r Microbiology, and Pharmacology and Cancer\r Biology, and Howard Hughes Medical Institute, Duke\r University Medical Center, Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary M.","family":"Cox","sequence":"additional","affiliation":[{"name":"Departments of Genetics, Medicine,\r Microbiology, and Pharmacology and Cancer\r Biology, and Howard Hughes Medical Institute, Duke\r University Medical Center, Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Perfect","sequence":"additional","affiliation":[{"name":"Departments of Genetics, Medicine,\r Microbiology, and Pharmacology and Cancer\r Biology, and Howard Hughes Medical Institute, Duke\r University Medical Center, Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Heitman","sequence":"additional","affiliation":[{"name":"Departments of Genetics, Medicine,\r Microbiology, and Pharmacology and Cancer\r Biology, and Howard Hughes Medical Institute, Duke\r University Medical Center, Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2000,12,19]]},"reference":[{"key":"e_1_3_5_1_2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1439-0507.1994.tb00418.x","volume":"37","author":"Knoke M","year":"1994","unstructured":"M Knoke, G Schwesinger Mycoses 37, 229\u2013233 (1994).","journal-title":"Mycoses"},{"key":"e_1_3_5_2_2","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1128\/CMR.8.4.515","volume":"8","author":"Mitchell T G","year":"1995","unstructured":"T G Mitchell, J R Perfect Clin Microbiol Rev 8, 515\u2013548 (1995).","journal-title":"Clin Microbiol Rev"},{"key":"e_1_3_5_3_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/9781555818241","volume-title":"Cryptococcus neoformans","author":"Casadevall A","year":"1998","unstructured":"A Casadevall, J R Perfect Cryptococcus neoformans (Am. 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