{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:43:20Z","timestamp":1791492200919,"version":"4.3.4"},"reference-count":24,"publisher":"National Academy of Sciences","issue":"7","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2000,3,28]]},"abstract":"<jats:p>TALL-1\/Blys\/BAFF is a member of the tumor necrosis factor (TNF) ligand superfamily that is functionally involved in B cell proliferation. Here, we describe B cell hyperplasia and autoimmune lupus-like changes in transgenic mice expressing TALL-1 under the control of a \u03b2-actin promoter. The TALL-1 transgenic mice showed severe enlargement of spleen, lymph nodes, and Peyer's patches because of an increased number of B220+ cells. The transgenic mice also had hypergammaglobulinemia contributed by elevations of serum IgM, IgG, IgA, and IgE. In addition, a phenotype similar to autoimmune lupus-like disease was also seen in TALL-1 transgenic mice, characterized by the presence of autoantibodies to nuclear antigens and immune complex deposits in the kidney. Prolonged survival and hyperactivity of transgenic B cells may contribute to the autoimmune lupus-like phenotype in these animals. Our studies further confirm TALL-1 as a stimulator of B cells that affect Ig production. Thus, TALL-1 may be a primary mediator in B cell-associated autoimmune diseases.<\/jats:p>","DOI":"10.1073\/pnas.97.7.3370","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T13:37:36Z","timestamp":1343223456000},"page":"3370-3375","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":590,"title":["Severe B cell hyperplasia and autoimmune disease in TALL-1 transgenic mice"],"prefix":"10.1073","volume":"97","author":[{"given":"Sanjay D.","family":"Khare","sequence":"first","affiliation":[{"name":"Departments of Cell Biology, Pharmacology, Pathology, Protein Chemistry, Process Science, and Cancer, Amgen, 1 Amgen Center Drive, Thousand Oaks, CA 91320-1799"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildiko","family":"Sarosi","sequence":"additional","affiliation":[{"name":"Departments of Cell Biology, Pharmacology, Pathology, Protein Chemistry, Process Science, and Cancer, Amgen, 1 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