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We identified a previously unreported transcript, designated\n                    <jats:italic>BHLHB1<\/jats:italic>\n                    (for basic domain, helix\u2013loop\u2013helix protein, class B, 1) that had been activated by the translocation.\n                    <jats:italic>BHLHB1<\/jats:italic>\n                    mapped to the region of chromosome 21 that has been proposed to be responsible, at least in part, for the learning deficits seen in children with Down's syndrome. Although\n                    <jats:italic>BHLHB1<\/jats:italic>\n                    expression normally is restricted to neural tissues, T-cell lymphoblasts with the t(14;21)(q11.2;q22) also expressed high levels of\n                    <jats:italic>BHLHB1<\/jats:italic>\n                    mRNA. Expression of\n                    <jats:italic>BHLHB1<\/jats:italic>\n                    dramatically inhibited E2A-mediated transcription activation in NIH 3T3 fibroblasts and Jurkat T cells. This observation suggests that\n                    <jats:italic>BHLHB1<\/jats:italic>\n                    , similar to\n                    <jats:italic>SCL\/TAL1<\/jats:italic>\n                    , may exert a leukemogenic effect through a functional inactivation of E2A or related proteins.\n                  <\/jats:p>","DOI":"10.1073\/pnas.97.7.3497","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:38:21Z","timestamp":1027679901000},"page":"3497-3502","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":78,"title":["The t(14;21)(q11.2;q22) chromosomal translocation associated with T-cell acute lymphoblastic leukemia activates the\n                    <i>BHLHB1<\/i>\n                    gene"],"prefix":"10.1073","volume":"97","author":[{"given":"Junjie","family":"Wang","sequence":"first","affiliation":[{"name":"Departments of Cancer Genetics, Biochemistry, Clinical Cytogenetics, and Pediatrics, Roswell Park Cancer Institute, Buffalo, NY 14263; Division of Hematology\/Oncology, Miami Children's Hospital, Miami, FL 33155; Department of Human Genetics, University of Alabama, Birmingham, AL 35294; and Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila N.","family":"Jani-Sait","sequence":"additional","affiliation":[{"name":"Departments of Cancer Genetics, Biochemistry, Clinical Cytogenetics, and Pediatrics, Roswell Park Cancer Institute, Buffalo, NY 14263; Division of Hematology\/Oncology, Miami Children's Hospital, Miami, FL 33155; Department of Human Genetics, University of Alabama, Birmingham, AL 35294; and Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique A.","family":"Escalon","sequence":"additional","affiliation":[{"name":"Departments of Cancer Genetics, Biochemistry, 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