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The two homologs, zfBMAL1 and zfBMAL2, contain conserved basic helix\u2013loop\u2013helix-PAS (Period-Arylhydrocarbon receptor-Singleminded) domains but diverge in the carboxyl termini, thus bearing different transcriptional activation potential. As for\n                    <jats:italic>zfClock<\/jats:italic>\n                    , the expression of both\n                    <jats:italic>zfBmal<\/jats:italic>\n                    s oscillates in most tissues in the animal. However, in many tissues, the peak, levels, and kinetics of expression are different between the two genes and for the same gene from tissue to tissue. These results support the existence of independent peripheral oscillators and suggest that zfBMAL1 and zfBMAL2 may exert distinct circadian functions, interacting differentially with zfCLOCK at various times in different tissues. Our findings also indicate that multiple controls may be exerted by the central clock and\/or that peripheral oscillators can differentially interpret central clock signals.\n                  <\/jats:p>","DOI":"10.1073\/pnas.97.8.4339","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:35:07Z","timestamp":1027679707000},"page":"4339-4344","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":126,"title":["Asynchronous oscillations of two zebrafish CLOCK partners reveal differential clock control and function"],"prefix":"10.1073","volume":"97","author":[{"given":"Nicolas","family":"Cermakian","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Universit\u00e9 Louis Pasteur, B.P. 163, 67404 Illkirch-Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Whitmore","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Universit\u00e9 Louis Pasteur, B.P. 163, 67404 Illkirch-Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas S.","family":"Foulkes","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Universit\u00e9 Louis Pasteur, B.P. 163, 67404 Illkirch-Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Sassone-Corsi","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Universit\u00e9 Louis Pasteur, B.P. 163, 67404 Illkirch-Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2000,4,11]]},"reference":[{"key":"e_1_3_4_1_2","first-page":"871","volume":"362","author":"Sassone-Corsi P","year":"1998","unstructured":"P Sassone-Corsi Nature (London) 362, 871\u2013874 (1998).","journal-title":"Nature (London)"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0092-8674(00)80566-8","volume":"96","author":"Dunlap J C","year":"1999","unstructured":"J C Dunlap Cell 96, 271\u2013290 (1999).","journal-title":"Cell"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1126\/science.8171325","volume":"264","author":"Vitaterna M H","year":"1994","unstructured":"M H Vitaterna, D P King, A M Chang, J M Kornhauser, P L Lowrey, J D McDonald, W F Dove, L H Pinto, F W Turek, J S Takahashi Science 264, 719\u2013725 (1994).","journal-title":"Science"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0092-8674(00)80245-7","volume":"89","author":"King D P","year":"1997","unstructured":"D P King, Y Zhao, A M Sangoram, L D Wilsbacher, M Tanaka, M P Antoch, T D Steeves, M H Vitaterna, J M Kornhauser, P L Lowrey, et al. 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