{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:50:08Z","timestamp":1791906608441,"version":"4.3.4"},"reference-count":12,"publisher":"National Academy of Sciences","issue":"2","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2001,1,16]]},"abstract":"<jats:p>We have identified a family of resistin-like molecules (RELMs) in rodents and humans. Resistin is a hormone produced by fat cells. RELM\u03b1 is a secreted protein that has a restricted tissue distribution with highest levels in adipose tissue. Another family member, RELM\u03b2, is a secreted protein expressed only in the gastrointestinal tract, particularly the colon, in both mouse and human. RELM\u03b2 gene expression is highest in proliferative epithelial cells and is markedly increased in tumors, suggesting a role in intestinal proliferation. Resistin and the RELMs share a cysteine composition and other signature features. Thus, the RELMs together with resistin comprise a class of tissue-specific signaling molecules.<\/jats:p>","DOI":"10.1073\/pnas.98.2.502","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:45:09Z","timestamp":1027680309000},"page":"502-506","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":509,"title":["A family of tissue-specific resistin-like molecules"],"prefix":"10.1073","volume":"98","author":[{"given":"Claire M.","family":"Steppan","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Division of Gastroenterology, Department of Medicine, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth J.","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Division of Gastroenterology, Department of Medicine, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Wright","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Division of Gastroenterology, Department of Medicine, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savitha","family":"Bhat","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Division of Gastroenterology, Department of Medicine, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronadip R.","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Division of Gastroenterology, Department of Medicine, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte Y.","family":"Dai","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Division of Gastroenterology, Department of Medicine, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory H.","family":"Enders","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Division of Gastroenterology, Department of Medicine, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra G.","family":"Silberg","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Division of Gastroenterology, Department of Medicine, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Wen","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Division of Gastroenterology, Department of Medicine, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary D.","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Division of Gastroenterology, Department of Medicine, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell A.","family":"Lazar","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Division of Gastroenterology, Department of Medicine, and The Penn Diabetes Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2001,1,16]]},"reference":[{"key":"e_1_3_4_1_2","unstructured":"Steppan C. M. Bailey S. T. Bhat S. Wright C. M. Brown E. J. Banerjee R. R. Ahima R. S. & Lazar M. A. (2001) Nature (London) in press."},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1210\/endo.135.2.8033830","volume":"135","author":"Chawla A","year":"1994","unstructured":"A Chawla, E J Schwarz, D D Dimaculangan, M A Lazar Endocrinology 135, 798\u2013800 (1994).","journal-title":"Endocrinology"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1101\/gad.14.1.45","volume":"14","author":"Huang E Y","year":"2000","unstructured":"E Y Huang, J Zhang, E A Miska, M G Guenther, T Kouzarides, M A Lazar Genes Dev 14, 45\u201354 (2000).","journal-title":"Genes Dev"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"G1445","DOI":"10.1152\/ajpcell.1998.275.3.C675","volume":"275","author":"Yang H","year":"1998","unstructured":"H Yang, W Jiang, E E Furth, X Wen, J P Katz, R K Sellon, D G Silberg, T M Antalis, C W Schweinfest, G D Wu Am J Physiol 275, G1445\u2013G1453 (1998).","journal-title":"Am J Physiol"},{"key":"e_1_3_4_5_2","first-page":"573","volume":"183","author":"Williams L","year":"1991","unstructured":"L Williams, L Bell Embryology 183, 573\u2013578 (1991).","journal-title":"Embryology"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.1350108","volume":"256","author":"Su L-K","year":"1992","unstructured":"L-K Su, K W Kinzler, B Vogelstein, A C Preisinger, A R Moser, C Luongo, K A Gould, W F Dove Science 256, 668\u2013670 (1992).","journal-title":"Science"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"6718","DOI":"10.4049\/jimmunol.163.12.6718","volume":"163","author":"O'Neil D A","year":"1999","unstructured":"D A O'Neil, E M Porter, D Elewaut, G M Anderson, L Eckmann, T Ganz, M F Kagnoff J Immunol 163, 6718\u20136724 (1999).","journal-title":"J Immunol"},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/0016-5085(95)90087-X","volume":"108","author":"Barnard J A","year":"1995","unstructured":"J A Barnard, R D Beauchamp, W E Russell, R N Dubois, R J Coffey Gastroenterology 108, 564\u2013580 (1995).","journal-title":"Gastroenterology"},{"key":"e_1_3_4_9_2","first-page":"G174","volume":"263","author":"Roth K A","year":"1992","unstructured":"K A Roth, S Kim, J I Gordon Am J Physiol 263, G174\u2013G180 (1992).","journal-title":"Am J Physiol"},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.ph.58.030196.001345","volume":"58","author":"Sands B E","year":"1996","unstructured":"B E Sands, D K Podolsky Annu Rev Physiol 58, 253\u2013273 (1996).","journal-title":"Annu Rev Physiol"},{"key":"e_1_3_4_11_2","first-page":"385","volume":"3","author":"Campbell I D","year":"1993","unstructured":"I D Campbell, P Bork Curr Biol 3, 385\u2013392 (1993).","journal-title":"Curr Biol"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1093\/emboj\/19.15.4046","volume":"19","author":"Holcomb I N","year":"2000","unstructured":"I N Holcomb, R C Kabakoff, B Chan, T W Baker, A Gurney, W Henzel, C Nelson, H B Lowman, B D Wright, N J Skelton, et al. EMBO J 19, 4046\u20134055 (2000).","journal-title":"EMBO J"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.98.2.502","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T08:35:47Z","timestamp":1682152547000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.98.2.502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1,16]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,1,16]]}},"alternative-id":["10.1073\/pnas.98.2.502"],"URL":"https:\/\/doi.org\/10.1073\/pnas.98.2.502","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,1,16]]},"assertion":[{"value":"2000-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-11-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2001-01-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}