{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:20:28Z","timestamp":1791426028951,"version":"4.3.3"},"reference-count":28,"publisher":"National Academy of Sciences","issue":"2","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2001,1,16]]},"abstract":"<jats:p>\n                    Adrenomedullin, a recently identified potent vasodilator, is\n expressed widely and has been suggested to have functions ranging from\n reproduction to blood pressure regulation. To elucidate these functions\n and define more precisely sites of Adm expression, we replaced the\n coding region of the\n                    <jats:italic>Adm<\/jats:italic>\n                    gene in mice with a sequence\n encoding enhanced green fluorescent protein while leaving the\n                    <jats:italic>Adm<\/jats:italic>\n                    promoter intact. We find that\n                    <jats:italic>Adm<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    embryos die at midgestation with\n extreme hydrops fetalis and cardiovascular abnormalities, including\n overdeveloped ventricular trabeculae and underdeveloped arterial walls.\n These data suggest that genetically determined absence of\n                    <jats:italic>Adm<\/jats:italic>\n                    may be one cause of nonimmune hydrops fetalis in\n humans.\n                  <\/jats:p>","DOI":"10.1073\/pnas.98.2.615","type":"journal-article","created":{"date-parts":[[2012,7,26]],"date-time":"2012-07-26T18:42:31Z","timestamp":1343328151000},"page":"615-619","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":381,"title":["Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene"],"prefix":"10.1073","volume":"98","author":[{"given":"Kathleen M.","family":"Caron","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of\r North Carolina, Chapel Hill, NC 27599-7525"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Smithies","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of\r North Carolina, Chapel Hill, NC 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