{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:47:48Z","timestamp":1791308868505,"version":"4.3.1"},"reference-count":47,"publisher":"National Academy of Sciences","issue":"3","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2001,1,30]]},"abstract":"<jats:p>\n                    Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant\n cancer syndrome, characterized primarily by multiple tumors in the\n parathyroid glands, endocrine pancreas, and anterior pituitary. Other\n tumors, including gastrinoma, carcinoid, adrenal cortical tumors,\n angiofibroma, collagenoma, and lipoma, also occur in some patients.\n Individuals with MEN1 almost always have loss-of-function mutations in\n the\n                    <jats:italic>MEN1<\/jats:italic>\n                    gene on chromosome 11, and endocrine tumors\n arising in these patients usually show somatic loss of the remaining\n wild-type allele. To examine the role of\n                    <jats:italic>MEN1<\/jats:italic>\n                    in tumor\n formation, a mouse model was generated through homologous recombination\n of the mouse homolog\n                    <jats:italic>Men1<\/jats:italic>\n                    . Homozygous mice die\n                    <jats:italic>in\n utero<\/jats:italic>\n                    at embryonic days 11.5\u201312.5, whereas heterozygous mice\n develop features remarkably similar to those of the human disorder. As\n early as 9 months, pancreatic islets show a range of lesions from\n hyperplasia to insulin-producing islet cell tumors, and parathyroid\n adenomas are also frequently observed. Larger, more numerous tumors\n involving pancreatic islets, parathyroids, thyroid, adrenal cortex, and\n pituitary are seen by 16 months. All of the tumors tested to date show\n loss of the wild-type\n                    <jats:italic>Men1<\/jats:italic>\n                    allele, further supporting\n its role as a tumor suppressor gene.\n                  <\/jats:p>","DOI":"10.1073\/pnas.98.3.1118","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:45:09Z","timestamp":1027680309000},"page":"1118-1123","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":381,"title":["A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors"],"prefix":"10.1073","volume":"98","author":[{"given":"Judy S.","family":"Crabtree","sequence":"first","affiliation":[{"name":"National Human Genome Research Institute, National\r Cancer Institute, and National Institute of Diabetes and\r Digestive and Kidney Diseases, National Institutes of Health,\r Bethesda, MD 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