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Concomitant nucleosome assembly protects the discontinuous mismatch-containing strands from excessive degradation by MMR machinery. Such protection is also demonstrated in a defined purified system that supports both mismatch correction and CAF-I-dependent histone H3\u2013H4 deposition reactions. In addition, we find that the mismatch recognition factor MutS\u03b1 suppresses CAF-I-dependent histone H3\u2013H4 deposition in a mismatch-dependent manner. We suggest that there is active crosstalk between MMR and replication-dependent nucleosome assembly during the correction of DNA replication errors and, as a result, the nascent mismatch-containing strands are degraded in a controlled manner.<\/jats:p>","DOI":"10.1073\/pnas.1015914108","type":"journal-article","created":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T04:07:07Z","timestamp":1296533227000},"page":"2753-2758","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":59,"title":["CAF-I-dependent control of degradation of the discontinuous strands during mismatch repair"],"prefix":"10.1073","volume":"108","author":[{"given":"Lyudmila Y.","family":"Kadyrova","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Southern Illinois University School of Medicine, Carbondale, IL 62901"}]},{"given":"Elena Rodriges","family":"Blanko","sequence":"additional","affiliation":[{"name":"Department of 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