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Among these were tumors with high relative expression of neuroendocrine genes and of type II pneumocyte genes, respectively. Retrospective analysis revealed a less favorable outcome for the adenocarcinomas with neuroendocrine gene expression. The diagnostic potential of expression profiling is emphasized by its ability to discriminate primary lung adenocarcinomas from metastases of extra-pulmonary origin. These results suggest that integration of expression profile data with clinical parameters could aid in diagnosis of lung cancer patients.<\/jats:p>","DOI":"10.1073\/pnas.191502998","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:35:07Z","timestamp":1027694107000},"page":"13790-13795","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1997,"title":["Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses"],"prefix":"10.1073","volume":"98","author":[{"given":"Arindam","family":"Bhattacharjee","sequence":"first","affiliation":[{"name":"Departments of Adult Oncology and Pediatric Oncology, Dana\u2013Farber Cancer Institute, Harvard Medical School, and Department of Biostatistics, Harvard School of Public Health, 44 Binney Street, Boston, MA 02115; Departments of Surgery and Pathology, Brigham and Women's Hospital, HMS, 75 Francis Street, 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