{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T18:23:56Z","timestamp":1768674236850,"version":"3.49.0"},"reference-count":0,"publisher":"Proceedings of the National Academy of Sciences","issue":"9","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1973,9]]},"abstract":"<jats:p>Some well-defined statistical regularities characterize the change in period (\u03c4) of cockroach circadian oscillations subjected to a large temperature step. These are explainable in terms of the well-known temperature-compensation (homeostasis) of \u03c4 of circadian oscillations. The same regularities are detectable in published data on the effect of several other variables affecting several other circadian oscillations. The proposition is then developed that the temperature-compensation of \u03c4 is only a special case of a general homeostatic conservation of the frequency of circadian oscillations in the face of all changes they are likely to encounter in the cell. Such a general homeostasis of \u03c4 is a functional prerequisite for an oscillator to function as a useful \u201cclock.\u201d<\/jats:p>","DOI":"10.1073\/pnas.70.9.2697","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T06:45:25Z","timestamp":1149057925000},"page":"2697-2701","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":95,"title":["General Homeostasis of the Frequency of Circadian Oscillations"],"prefix":"10.1073","volume":"70","author":[{"given":"Colin S.","family":"Pittendrigh","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Stanford University, Stanford, California 94305"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia C.","family":"Caldarola","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Stanford University, Stanford, California 94305"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"341","published-online":{"date-parts":[[1973,9]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.70.9.2697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T14:45:37Z","timestamp":1649861137000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.70.9.2697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1973,9]]}},"alternative-id":["10.1073\/pnas.70.9.2697"],"URL":"https:\/\/doi.org\/10.1073\/pnas.70.9.2697","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,9]]},"assertion":[{"value":"1973-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}