{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:08:46Z","timestamp":1781104126876,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"5","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1991,3]]},"abstract":"<jats:p>The p53 gene is a frequent target of mutation in a wide variety of human cancers. Previously, it was reported that conditional expression of wild-type p53 protein in a cell line (GM47.23) derived from a human glioblastoma multiform tumor had a negative effect on cell proliferation. We have now investigated the effect that induction of wild-type p53 protein in this cell line has on the expression of the proliferating-cell nuclear antigen gene. The proliferating-cell nuclear antigen gene encodes a nuclear protein that is an auxiliary factor of DNA polymerase delta and part of the DNA replication machinery of the cell. We show that inhibition of cell cycle progression into S-phase after induction of wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen mRNA and protein expression.<\/jats:p>","DOI":"10.1073\/pnas.88.5.1958","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T07:55:03Z","timestamp":1149062103000},"page":"1958-1962","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":162,"title":["Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression."],"prefix":"10.1073","volume":"88","author":[{"given":"W E","family":"Mercer","sequence":"first","affiliation":[{"name":"Department of Pathology, Temple University School of Medicine, Philadelphia, PA 19140."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M T","family":"Shields","sequence":"additional","affiliation":[{"name":"Department of Pathology, Temple University School of Medicine, Philadelphia, PA 19140."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Temple University School of Medicine, Philadelphia, PA 19140."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Appella","sequence":"additional","affiliation":[{"name":"Department of Pathology, Temple University School of Medicine, Philadelphia, PA 19140."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S J","family":"Ullrich","sequence":"additional","affiliation":[{"name":"Department of Pathology, Temple University School of Medicine, Philadelphia, PA 19140."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1991,3]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.88.5.1958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:15:49Z","timestamp":1649855749000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.88.5.1958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,3]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1991,3]]}},"alternative-id":["10.1073\/pnas.88.5.1958"],"URL":"https:\/\/doi.org\/10.1073\/pnas.88.5.1958","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,3]]},"assertion":[{"value":"1991-03-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}