{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:03:53Z","timestamp":1781111033783,"version":"3.54.1"},"reference-count":0,"publisher":"National Academy of Sciences","issue":"10","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1992,5,15]]},"abstract":"<jats:p>Three equivocal amino acid sequences were synthesized that are predicted to be alpha-helical from amino acid preference but are found to be primarily beta-strand from x-ray diffraction of their respective proteins. In some solvent systems we recover the alpha-helical structure predicted by amino acid preference, whereas in other systems we mimic the interior of the protein and produce a beta-strand. These results are experimental proof that the environment is important in determining the secondary structure formed by an amino acid sequence; therefore schemes that predict secondary structure from amino acid sequence alone can never be totally successful.<\/jats:p>","DOI":"10.1073\/pnas.89.10.4462","type":"journal-article","created":{"date-parts":[[2006,5,31]],"date-time":"2006-05-31T08:01:17Z","timestamp":1149062477000},"page":"4462-4465","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":197,"title":["Environment affects amino acid preference for secondary structure."],"prefix":"10.1073","volume":"89","author":[{"given":"L","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biophysics, Oregon State University, Corvallis 97331-6503."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"W C","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, Oregon State University, Corvallis 97331-6503."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1992,5,15]]},"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.89.10.4462","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T13:18:02Z","timestamp":1649855882000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.89.10.4462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,5,15]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1992,5,15]]}},"alternative-id":["10.1073\/pnas.89.10.4462"],"URL":"https:\/\/doi.org\/10.1073\/pnas.89.10.4462","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,5,15]]},"assertion":[{"value":"1992-05-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}