{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T01:48:30Z","timestamp":1775958510923,"version":"3.50.1"},"reference-count":61,"publisher":"Proceedings of the National Academy of Sciences","issue":"18","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1997,9,2]]},"abstract":"<jats:p>\n            Senescence, the decline in survivorship and fertility with increasing age, is a near-universal property of organisms. Senescence and limited lifespan are thought to arise because weak natural selection late in life allows the accumulation of mutations with deleterious late-age effects that are either neutral (the mutation accumulation hypothesis) or beneficial (the antagonistic pleiotropy hypothesis) early in life. Analyses of\n            <jats:italic>Drosophila<\/jats:italic>\n            spontaneous mutations, patterns of segregating variation and covariation, and lines selected for late-age fertility have implicated both classes of mutation in the evolution of aging, but neither their relative contributions nor the properties of individual loci that cause aging in nature are known. To begin to dissect the multiple genetic causes of quantitative variation in lifespan, we have conducted a genome-wide screen for quantitative trait loci (QTLs) affecting lifespan that segregate among a panel of recombinant inbred lines using a dense molecular marker map. Five autosomal QTLs were mapped by composite interval mapping and by sequential multiple marker analysis. The QTLs had large sex-specific effects on lifespan and age-specific effects on survivorship and mortality and mapped to the same regions as candidate genes with fertility, cellular aging, stress resistance and male-specific effects. Late age-of-onset QTL effects are consistent with the mutation accumulation hypothesis for the evolution of senescence, and sex-specific QTL effects suggest a novel mechanism for maintaining genetic variation for lifespan.\n          <\/jats:p>","DOI":"10.1073\/pnas.94.18.9734","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:31:44Z","timestamp":1027693904000},"page":"9734-9739","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":245,"title":["Sex-specific quantitative trait loci affecting longevity in\n            <i>Drosophila\u2009melanogaster<\/i>"],"prefix":"10.1073","volume":"94","author":[{"given":"Sergey V.","family":"Nuzhdin","sequence":"first","affiliation":[{"name":"Department of Genetics, Box 7614, North Carolina State University, Raleigh, NC 27695-7614; The Institute of Molecular Genetics, Kurchatov Square, Moscow 123182, Russia; and Department of Statistics, Box 8203, North Carolina State University, Raleigh, NC 27695-8203"}]},{"given":"Elena G.","family":"Pasyukova","sequence":"additional","affiliation":[{"name":"Department of Genetics, Box 7614, North Carolina State University, Raleigh, NC 27695-7614; The Institute of Molecular Genetics, Kurchatov Square, Moscow 123182, Russia; and Department of Statistics, Box 8203, North Carolina State University, Raleigh, NC 27695-8203"}]},{"given":"Christy L.","family":"Dilda","sequence":"additional","affiliation":[{"name":"Department of Genetics, Box 7614, North Carolina State University, Raleigh, NC 27695-7614; The Institute of Molecular Genetics, Kurchatov Square, Moscow 123182, Russia; and Department of Statistics, Box 8203, North Carolina State University, Raleigh, NC 27695-8203"}]},{"given":"Zhao-Bang","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Genetics, Box 7614, North Carolina State University, Raleigh, NC 27695-7614; The Institute of Molecular Genetics, Kurchatov Square, Moscow 123182, Russia; and Department of Statistics, Box 8203, North Carolina State University, Raleigh, NC 27695-8203"}]},{"given":"Trudy F. 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