{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:24:39Z","timestamp":1781108679824,"version":"3.54.1"},"reference-count":31,"publisher":"National Academy of Sciences","issue":"10","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1998,5,12]]},"abstract":"<jats:p>\n                    In\n                    <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    , tryptophan pathway genes are induced in response to starvation, wounding, and pathogen attack, resulting in increased production of tryptophan and secondary metabolites important for development and defense. The\n                    <jats:italic>Arabidopsis<\/jats:italic>\n                    tryptophan pathway therefore provides an ideal system for elucidating how environmental stimuli are transduced into changes in plant gene expression. To characterize the factors that regulate the first gene in the pathway,\n                    <jats:italic>ASA1<\/jats:italic>\n                    , which is the key point of control, we have isolated\n                    <jats:underline>a<\/jats:underline>\n                    ltered\n                    <jats:underline>t<\/jats:underline>\n                    ryptophan\n                    <jats:underline>r<\/jats:underline>\n                    egulation (\n                    <jats:italic>atr<\/jats:italic>\n                    ) mutants with deregulated expression of\n                    <jats:italic>ASA1<\/jats:italic>\n                    . One of these mutants,\n                    <jats:italic>atr1D<\/jats:italic>\n                    is dominant for increased transcription of\n                    <jats:italic>ASA1<\/jats:italic>\n                    in specific seedling tissues. We have used\n                    <jats:italic>atr1D<\/jats:italic>\n                    to clone the\n                    <jats:italic>ATR1<\/jats:italic>\n                    gene based on its map position.\n                    <jats:italic>ATR1<\/jats:italic>\n                    encodes a Myb-like transcription factor that modulates\n                    <jats:italic>ASA1<\/jats:italic>\n                    expression. The\n                    <jats:italic>ATR1<\/jats:italic>\n                    transcript also includes a 5\u2032 regulatory region with three short ORFs, one of which is prematurely terminated by the\n                    <jats:italic>atr1D<\/jats:italic>\n                    mutation. Thus,\n                    <jats:italic>ATR1<\/jats:italic>\n                    defines the first characterized tryptophan gene regulator in plants, and the\n                    <jats:italic>atr1D<\/jats:italic>\n                    mutation defines a sequence important for ATR1 expression.\n                  <\/jats:p>","DOI":"10.1073\/pnas.95.10.5655","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:35:50Z","timestamp":1027679750000},"page":"5655-5660","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":122,"title":["A Myb homologue, ATR1, activates tryptophan gene expression in\n                    <i>Arabidopsis<\/i>"],"prefix":"10.1073","volume":"95","author":[{"given":"Judith","family":"Bender","sequence":"first","affiliation":[{"name":"Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald R.","family":"Fink","sequence":"additional","affiliation":[{"name":"Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[1998,5,12]]},"reference":[{"key":"e_1_3_4_1_2","first-page":"921","volume":"7","author":"Radwanski E R","year":"1995","unstructured":"E R Radwanski, R L Last Plant Cell 7, 921\u2013934 (1995).","journal-title":"Plant Cell"},{"key":"e_1_3_4_2_2","first-page":"721","volume":"4","author":"Niyogi K K","year":"1992","unstructured":"K K Niyogi, G R Fink Plant Cell 4, 721\u2013733 (1992).","journal-title":"Plant Cell"},{"key":"e_1_3_4_3_2","first-page":"1011","volume":"5","author":"Niyogi K K","year":"1993","unstructured":"K K Niyogi, R L Last, G R Fink, B Keith Plant Cell 5, 1011\u20131027 (1993).","journal-title":"Plant Cell"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1104\/pp.110.1.51","volume":"110","author":"Li J","year":"1996","unstructured":"J Li, R L Last Plant Physiol 110, 51\u201359 (1996).","journal-title":"Plant Physiol"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1104\/pp.110.4.1159","volume":"110","author":"Kreps J A","year":"1996","unstructured":"J A Kreps, T Ponappa, W Dong, C D Town Plant Physiol 110, 1159\u20131165 (1996).","journal-title":"Plant Physiol"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/BF00331020","volume":"204","author":"Haughn G W","year":"1986","unstructured":"G W Haughn, C Somerville Mol Gen Genet 204, 430\u2013434 (1986).","journal-title":"Mol Gen Genet"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1104\/pp.93.4.1365","volume":"93","author":"Stasinopoulos T C","year":"1990","unstructured":"T C Stasinopoulos, R P Hangarter Plant Physiol 93, 1365\u20131369 (1990).","journal-title":"Plant Physiol"},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1046\/j.1365-313X.1993.04020403.x","volume":"4","author":"Konieczny A","year":"1993","unstructured":"A Konieczny, F M Ausubel Plant J 4, 403\u2013410 (1993).","journal-title":"Plant J"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1142\/9789814439701_0006","volume-title":"Methods in Arabidopsis Research","author":"Matallana E","year":"1992","unstructured":"E Matallana, C J Bell, P J Dunn, M Lu, J R Ecker Methods in Arabidopsis Research, eds C Koncz, N-H Chua, J Schell (World Scientific, Teaneck, NJ), pp. 144\u2013169 (1992)."},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1046\/j.1365-313X.1995.08050763.x","volume":"8","author":"Creusot F","year":"1995","unstructured":"F Creusot, E Fouilloux, M Dron, J Lafleuriel, G Picard, A Billault, D Le Paslier, D Cohen, M-E Chaboute, A Durr, et al. 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