{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:20:19Z","timestamp":1777497619813,"version":"3.51.4"},"reference-count":25,"publisher":"Proceedings of the National Academy of Sciences","issue":"10","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[1998,5,12]]},"abstract":"<jats:p>\n            The plant hormone ethylene regulates a variety of processes of growth and development. To identify components in the ethylene signal transduction pathway, we screened for ethylene-insensitive mutants in\n            <jats:italic>Arabidopsis thaliana<\/jats:italic>\n            and isolated a dominant\n            <jats:italic>etr2-1<\/jats:italic>\n            mutant. The\n            <jats:italic>etr2-1<\/jats:italic>\n            mutation confers ethylene insensitivity in several processes, including etiolated seedling elongation, leaf expansion, and leaf senescence. Double mutant analysis indicates that\n            <jats:italic>ETR2<\/jats:italic>\n            acts upstream of\n            <jats:italic>CTR1<\/jats:italic>\n            , which codes for a Raf-related protein kinase. We cloned the\n            <jats:italic>ETR2<\/jats:italic>\n            gene on the basis of its map position, and we found that it exhibits sequence homology to the ethylene receptor gene\n            <jats:italic>ETR1<\/jats:italic>\n            and the\n            <jats:italic>ETR1<\/jats:italic>\n            -like\n            <jats:italic>ERS<\/jats:italic>\n            gene.\n            <jats:italic>ETR2<\/jats:italic>\n            may thus encode a third ethylene receptor in\n            <jats:italic>Arabidopsis<\/jats:italic>\n            , transducing the hormonal signal through its \u201ctwo-component\u201d structure. Expression studies show that\n            <jats:italic>ETR2<\/jats:italic>\n            is ubiquitously expressed and has a higher expression in some tissues, including inflorescence and floral meristems, petals, and ovules.\n          <\/jats:p>","DOI":"10.1073\/pnas.95.10.5812","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:32:33Z","timestamp":1027693953000},"page":"5812-5817","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":437,"title":["<i>ETR2<\/i>\n            is an\n            <i>ETR1<\/i>\n            -like gene involved in ethylene signaling in\n            <i>Arabidopsis<\/i>"],"prefix":"10.1073","volume":"95","author":[{"given":"Hajime","family":"Sakai","sequence":"first","affiliation":[{"name":"Division of Biology, 156-29, California Institute of Technology, Pasadena, CA 91125; and Botany Department, Birge Hall, University of Wisconsin, Madison, WI 53706"}]},{"given":"Jian","family":"Hua","sequence":"additional","affiliation":[{"name":"Division of Biology, 156-29, California Institute of Technology, Pasadena, CA 91125; and Botany Department, Birge Hall, University of Wisconsin, Madison, WI 53706"}]},{"given":"Qianhong G.","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Biology, 156-29, California Institute of Technology, Pasadena, CA 91125; and Botany Department, Birge Hall, University of Wisconsin, Madison, WI 53706"}]},{"given":"Caren","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Biology, 156-29, California Institute of Technology, Pasadena, CA 91125; and Botany Department, Birge Hall, University of Wisconsin, Madison, WI 53706"}]},{"given":"Leonard J.","family":"Medrano","sequence":"additional","affiliation":[{"name":"Division of Biology, 156-29, California Institute of Technology, Pasadena, CA 91125; and Botany Department, Birge Hall, University of Wisconsin, Madison, WI 53706"}]},{"given":"Anthony B.","family":"Bleecker","sequence":"additional","affiliation":[{"name":"Division of Biology, 156-29, California Institute of Technology, Pasadena, CA 91125; and Botany Department, Birge Hall, University of Wisconsin, Madison, WI 53706"}]},{"given":"Elliot M.","family":"Meyerowitz","sequence":"additional","affiliation":[{"name":"Division of Biology, 156-29, California Institute of Technology, Pasadena, CA 91125; and Botany Department, Birge Hall, University of Wisconsin, Madison, WI 53706"}]}],"member":"341","published-online":{"date-parts":[[1998,5,12]]},"reference":[{"key":"e_1_3_4_1_2","volume-title":"Ethylene in Plant Biology","author":"Abeles F B","year":"1992","unstructured":"F B Abeles, P W Morgan, M E Saltveit Ethylene in Plant Biology (Academic, 2nd Ed., New York, 1992).","edition":"2"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1126\/science.274.5294.1914","volume":"274","author":"O\u2019Donnell P 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