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Leptin, PPAR\u03b1\/retinoid x receptor ligands, and FA all up-regulate PPAR\u03b1 and enzymes of FA oxidation and stimulate [\n            <jats:sup>3<\/jats:sup>\n            H]-palmitate oxidation in normal islets but not in islets from\n            <jats:italic>fa\/fa<\/jats:italic>\n            rats. Overexpression of normal OB-R in islets of\n            <jats:italic>fa\/fa<\/jats:italic>\n            rats corrects all of the foregoing abnormalities and reverses the diabetic phenotype. PPAR\u03b1 is a OB-R-dependent factor required for normal fat homeostasis in islet cells.\n          <\/jats:p>","DOI":"10.1073\/pnas.95.15.8898","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:39:15Z","timestamp":1027694355000},"page":"8898-8903","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":137,"title":["Role of peroxisome proliferator-activated receptor \u03b1 in disease of pancreatic \u03b2 cells"],"prefix":"10.1073","volume":"95","author":[{"given":"Yan-Ting","family":"Zhou","sequence":"first","affiliation":[{"name":"Gifford Laboratories for Diabetes Research, Center for Diabetes Research, Departments of Internal Medicine and Biochemistry, University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75235; and Veterans Affairs Medical Center, 4500 S. 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Lancaster Road, Dallas, TX 75216"}]},{"given":"Roger H.","family":"Unger","sequence":"additional","affiliation":[{"name":"Gifford Laboratories for Diabetes Research, Center for Diabetes Research, Departments of Internal Medicine and Biochemistry, University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75235; and Veterans Affairs Medical Center, 4500 S. 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