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Recent discoveries\n concerning the phenotypes of telomerase knockout mice, the consequences\n of telomerase reexpression in somatic cells, and genes that regulate\n senescence have provided striking molecular insights but also have\n uncovered important new questions. The objective of this review is to\n reconcile old observations with new molecular details and to focus\n attention on the key remaining puzzles.<\/jats:p>","DOI":"10.1073\/pnas.95.16.9078","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T14:42:40Z","timestamp":1027694560000},"page":"9078-9081","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":147,"title":["Can ends justify the means?: Telomeres and the mechanisms of replicative senescence and immortalization in mammalian cells"],"prefix":"10.1073","volume":"95","author":[{"given":"John M.","family":"Sedivy","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Cell Biology, and Biochemistry,\r Brown University, Providence, RI 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