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Analysis of all synthesized tetrahydropyran-arene compounds reveals a hindered sp\n            <jats:sup>2<\/jats:sup>\n            -sp\n            <jats:sup>3<\/jats:sup>\n            rotation, which results in rotational isomers or atropisomers affecting macrocyclization reactions. The latter could only be achieved by means of Horner\u2013Wadsworth\u2013Emmons olefination.\n          <\/jats:p>","DOI":"10.1073\/pnas.0401503101","type":"journal-article","created":{"date-parts":[[2004,7,27]],"date-time":"2004-07-27T00:24:39Z","timestamp":1090887879000},"page":"11980-11985","update-policy":"http:\/\/dx.doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":29,"title":["Toward the synthesis of the carbacylic\n            <i>ansa<\/i>\n            antibiotic kendomycin"],"prefix":"10.1073","volume":"101","author":[{"given":"Johann","family":"Mulzer","sequence":"first","affiliation":[{"name":"Institute of Organic Chemistry, University of Vienna, Waehringerstrasse 38, A-1090 Vienna, Austria"}]},{"given":"Stefan","family":"Pichlmair","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry, University of Vienna, Waehringerstrasse 38, A-1090 Vienna, Austria"}]},{"given":"Martin P.","family":"Green","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry, University of Vienna, Waehringerstrasse 38, A-1090 Vienna, Austria"}]},{"given":"Maria M. 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