{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:30:50Z","timestamp":1773203450515,"version":"3.50.1"},"reference-count":43,"publisher":"Proceedings of the National Academy of Sciences","issue":"36","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2006,9,5]]},"abstract":"<jats:p>Lymph node (LN) development depends on prenatal interactions occurring between LN inducer and LN organizer cells. We have distinguished defects in LN formation due to failure in embryonic development (<jats:italic>aly\/aly<\/jats:italic>) from defects in postnatal maturation (<jats:italic>Il2r<\/jats:italic>\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup><jats:italic>Rag2<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>). Both mutant strains form normal primordial LNs with differing fate. In<jats:italic>aly\/aly<\/jats:italic>mice, the LN primordium dissipates irreversibly late in gestation; in contrast,<jats:italic>Il2r<\/jats:italic>\u03b3<jats:sup>\u2212\/\u2212<\/jats:sup><jats:italic>Rag2<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>LN anlage persists for a week after birth but disperses subsequently, a process reversible by neonatal transfer of WT IL7r<jats:sup>+<\/jats:sup>TCR<jats:sup>+<\/jats:sup>T or natural killer (NK) cells, suggesting a role for IL7\/IL7r interactions. Thus, we reveal a unique stage of postnatal LN development during which mature lymphocytes and IL7\/IL7r interactions may play an important role.<\/jats:p>","DOI":"10.1073\/pnas.0604183103","type":"journal-article","created":{"date-parts":[[2006,8,25]],"date-time":"2006-08-25T00:36:13Z","timestamp":1156466173000},"page":"13457-13462","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":53,"title":["Role of T and NK cells and IL7\/IL7r interactions during neonatal maturation of lymph nodes"],"prefix":"10.1073","volume":"103","author":[{"given":"Mark C.","family":"Coles","sequence":"first","affiliation":[{"name":"Divisions of *Molecular Immunology and"}]},{"given":"Henrique","family":"Veiga-Fernandes","sequence":"additional","affiliation":[{"name":"Divisions of *Molecular Immunology and"}]},{"given":"Katie E.","family":"Foster","sequence":"additional","affiliation":[{"name":"Divisions of *Molecular Immunology and"}]},{"given":"Trisha","family":"Norton","sequence":"additional","affiliation":[{"name":"Divisions of *Molecular Immunology and"}]},{"given":"Stamatis N.","family":"Pagakis","sequence":"additional","affiliation":[{"name":"Confocal Microscopy and Image Analysis Laboratory, National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom"}]},{"given":"Ben","family":"Seddon","sequence":"additional","affiliation":[{"name":"Immune Cell Biology and"}]},{"given":"Dimitris","family":"Kioussis","sequence":"additional","affiliation":[{"name":"Divisions of *Molecular Immunology and"}]}],"member":"341","published-online":{"date-parts":[[2006,9,5]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2003.00063.x"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2002.18905.x"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.1.21"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1054"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80269-1"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.18.10132"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/17812"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.10.1467"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.18.2412"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/16852"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80588-9"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80292-7"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.4049\/jimmunol.155.4.1685","volume":"155","author":"Banks T. A.","year":"1995","unstructured":"T. A. Banks, B. T. Rouse, M. K. Kerley, P. J. Blair, V. L. Godfrey, N. A. Kuklin, D. M. Bouley, J. Thomas, S. Kanangat, M. L. Mucenski J. Immunol. 155, 1685\u20131693 (1995).","journal-title":"J. Immunol."},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8171322"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.moh.0000166496.18773.e3"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.5.621"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00479-X"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2003.00075.x"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2003.00073.x"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80589-0"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2003.08.002"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/9.4.507"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830240224"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/8780"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2003.00064.x"},{"key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.4049\/jimmunol.163.3.1584","volume":"163","author":"Matsumoto M.","year":"1999","unstructured":"M. Matsumoto, K. Iwamasa, P. D. Rennert, T. Yamada, R. Suzuki, A. Matsushima, M. Okabe, S. Fujita, M. Yokoyama J. Immunol. 163, 1584\u20131591 (1999).","journal-title":"J. Immunol."},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90047-0"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.2.377"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00980.x"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(95)00124-S"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/immu.200310005"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.2.804"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1665"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80371-4"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.5.2968"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.062621699"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00508-3"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.83"},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.4049\/jimmunol.157.12.5315","volume":"157","author":"Maraskovsky E.","year":"1996","unstructured":"E. Maraskovsky, M. Teepe, P. J. Morrissey, S. Braddy, R. E. Miller, D. H. Lynch, J. J. Peschon J. Immunol. 157, 5315\u20135323 (1996).","journal-title":"J. Immunol."},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.180.5.1955"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90030-G"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1604321"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.6.1317"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.0604183103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T16:18:04Z","timestamp":1683562684000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.0604183103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,5]]},"references-count":43,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2006,9,5]]}},"alternative-id":["10.1073\/pnas.0604183103"],"URL":"https:\/\/doi.org\/10.1073\/pnas.0604183103","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,5]]},"assertion":[{"value":"2006-05-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-09-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}