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Genetic linkage is known to be one such feature, and here we show theoretically that it can introduce a more sinister flaw: when there is complete linkage between loci affecting fitness and loci affecting mutation rate, positive natural selection and recurrent mutation can drive mutation rates in an adapting population to intolerable levels. We discuss potential implications of this finding for the early establishment of recombination, the evolutionary fate of asexual populations, and immunological clearance of clonal pathogens.<\/jats:p>","DOI":"10.1073\/pnas.0607280104","type":"journal-article","created":{"date-parts":[[2007,4,4]],"date-time":"2007-04-04T03:57:16Z","timestamp":1175659036000},"page":"6266-6271","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":75,"title":["Complete genetic linkage can subvert natural selection"],"prefix":"10.1073","volume":"104","author":[{"given":"Philip J.","family":"Gerrish","sequence":"first","affiliation":[{"name":"Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501;"},{"name":"Instituto de Ecologia, Universidad Aut\u00f3noma Nacional de M\u00e9xico, Apartado Postal 70-275, Ciudad Universitaria, 04510 Distrito Federal, 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